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Report error Found 200 of affinity data for UniProtKB/TrEMBL: O95718
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312140(US9604931, 15g | 6,8-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataKi:  0.480nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312151(US9604931, 15i | (E)-6,8-dihydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  1.66nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312133(US9604931, 12z)
Affinity DataKi:  3nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312096(US9604931, 12u | 4-bromo-6,8-dihydroxy-2-(4-hydrox...)
Affinity DataKi:  3nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312149(US9604931, 15h | 6,8-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataKi:  3.03nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312139(US9604931, 15c | 2-(3-fluoro-4-hydroxyphenyl)-6,8-...)
Affinity DataKi:  3.96nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at ZFP-fused ERRbeta LBD expressed in HEK293 cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312134(US9604931, 14I | 4-bromo-6-methoxy-2-(4-methoxyphe...)
Affinity DataKi:  6nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312135(US9604931, 14m | 6,8-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataKi:  7nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 8.70nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233271(CHEMBL4071073)
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50427842(CHEMBL2326072)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50455427(CHEMBL4206963)
Affinity DataEC50:  20nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50455420(CHEMBL4217033)
Affinity DataEC50:  31nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50427834(CHEMBL2326068)
Affinity DataIC50: 41nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50455417(CHEMBL4211016)
Affinity DataEC50:  45nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312136(US9604931, 14k | 4-bromo-6-hydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  46nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM310198(US9604931, 12b | 4-bromo-6-hydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  49nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233269(CHEMBL4100590)
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50212173(7-bromo-6H-chromeno[4,3-b]quinoline-3,9-diol | CHE...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM485072(US10934303, Example 87 | US10934303, Cmpd No. 27a)
Affinity DataIC50: 70nMAssay Description:ERRα/ERRβ/ERα : In an ERR beta binding assay, GST-bound ERR alpha LBD was used so that a final concentration was 10 nM and a fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM544469(87 | US11285226, Compound 27a)
Affinity DataIC50: 70nMAssay Description:In an ERR alpha binding assay, GST-bound ERR alpha LBD was used, and all experiments other than that was the same as the ERR gamma binding assay.In a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

LigandPNGBDBM50212166(7-chloro-6H-chromeno[4,3-b]quinoline-3,9-diol | CH...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50455402(CHEMBL4204689)
Affinity DataEC50:  90nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50212172(3,9-dihydroxy-6H-chromeno[4,3-b]quinoline-7-carbon...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50427836(CHEMBL2326070)
Affinity DataIC50: 112nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427841(CHEMBL2326073)
Affinity DataIC50: 121nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312137(US9604931, 15a | 6-hydroxy-2-(4-hydroxyphenyl)-4-p...)
Affinity DataKi:  130nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

LigandPNGBDBM50427835(CHEMBL2326069)
Affinity DataIC50: 151nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427838(CHEMBL2326076)
Affinity DataIC50: 185nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233266(CHEMBL4092854)
Affinity DataIC50: 210nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50171724(4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol | 4-bro...)
Affinity DataIC50: 212nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171726(4-chloro-2-(4-hydroxyphenyl)quinolin-6-ol | 4-Chlo...)
Affinity DataIC50: 213nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312138(US9604931, 15b | 6-hydroxy-2-(4-hydroxyphenol)-4-(...)
Affinity DataKi:  252nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233264(CHEMBL4085105)
Affinity DataIC50: 300nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50427840(CHEMBL2326074)
Affinity DataIC50: 331nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233267(CHEMBL4084142)
Affinity DataIC50: 350nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM19459(Prunetol | Genisteol | CHEMBL44 | US8552057, 2 | c...)
Affinity DataIC50: 395nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50427839(CHEMBL2326075)
Affinity DataIC50: 436nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50171712(6-Hydroxy-2-(4-hydroxy-phenyl)-quinoline-4-carboni...)
Affinity DataIC50: 455nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171727(2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol | 2-(4-...)
Affinity DataIC50: 504nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50212165(7-(3-chlorophenyl)-6H-chromeno[4,3-b]quinoline-3,9...)
Affinity DataIC50: 504nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50212161(7-vinyl-6H-chromeno[4,3-b]quinoline-3,9-diol | CHE...)
Affinity DataIC50: 526nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50212163(7-(4-methoxyphenyl)-6H-chromeno[4,3-b]quinoline-3,...)
Affinity DataIC50: 549nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233273(CHEMBL4064664)
Affinity DataIC50: 550nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50427837(CHEMBL2326071)
Affinity DataIC50: 566nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50233265(CHEMBL4065193)
Affinity DataIC50: 600nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50212170(7-ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diol | C...)
Affinity DataIC50: 624nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM50455428(CHEMBL4205664)
Affinity DataEC50:  630nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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