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Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  4nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1E receptor in human cortical homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  6.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50091438((E)-3-(3,4-dichlorophenyl)-N-(5-(4-(5-hydroxy-1H-i...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for 5-hydroxytryptamine 1E receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM31034(MLS000120058 | CHEMBL26655 | SMR000096975 | cid_15...)
Affinity DataEC50:  6.78nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  7.24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50456743(CHEMBL4217810)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50456726(CHEMBL4218231)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50456745(CHEMBL4207302)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  11.0nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM84994(NSC_163091 | CAS_163091 | ORG-5222)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM30727(cid_6603611 | MLS000038861 | 2-(5-butyl-1H-indol-3...)
Affinity DataEC50:  11.3nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataEC50:  15.7nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM31021(MLS000093713 | cid_51703 | 3-(1-ethyl-1,2,3,6-tetr...)
Affinity DataEC50:  23.9nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM30708(METHYSERGIDE MALEATE | SMR000058483 | (6aR,9R)-N-[...)
Affinity DataEC50:  37.5nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM31005(MIANSERIN HYDROCHLORIDE | SMR000058472 | MLS000069...)
Affinity DataEC50:  37.8nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50016479(CHEMBL160976 | LYSERGOL | CHEMBL39947 | cid_14987 ...)
Affinity DataKi:  42.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
LigandPNGBDBM50224302(CHEMBL31783)
Affinity DataKd:  43nMAssay Description:Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor using 1 uM LSD as masking ligand, activity is expressed as Kd.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50016479(CHEMBL160976 | LYSERGOL | CHEMBL39947 | cid_14987 ...)
Affinity DataKi:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  44nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  44.3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  44.3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50031942(CHEMBL1065 | Sansert | (6aR,9R)-4-Methyl-4,6,6a,7,...)
Affinity DataKi:  59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM30703(SMR000058526 | 2-[(4-tert-butyl-2,6-dimethyl-pheny...)
Affinity DataEC50:  87nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM81446(CAS_60-79-7 | NSC_104873 | ERGONOVINE)
Affinity DataKi:  87.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM81446(CAS_60-79-7 | NSC_104873 | ERGONOVINE)
Affinity DataKi:  88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50330860(Methylergometrine | CHEMBL1201356 | METHYLERGONOVI...)
Affinity DataKi:  89nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50330860(Methylergometrine | CHEMBL1201356 | METHYLERGONOVI...)
Affinity DataKi:  89.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM30707(3-(2-DIMETHYLAMINOETHYL)-5-METHOXYINDOLE | CHEMBL7...)
Affinity DataEC50:  92nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50241702([N-methyl-3H]LSD | CHEMBL463207 | lsd)
Affinity DataKi:  92.9nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM21342((4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[...)
Affinity DataKi:  93nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 99nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1E receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 99nMAssay Description:Binding affinity to 5HT1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataEC50:  99nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50449038(CHEMBL3126204 | US9212144, 15 (Ex. 17))
Affinity DataKi: <100nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM30701(N-OMEGA-METHYLTRYPTAMINE | MLS000069493 | N-methyl...)
Affinity DataEC50:  105nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50052339(2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Affinity DataKi:  110nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  120nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM81781(5-HT,omega-N-Me | 5-HT,a-Me)
Affinity DataKi:  120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM81781(5-HT,omega-N-Me | 5-HT,a-Me)
Affinity DataKi:  121nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM707625(rr-2b)
Affinity DataKi:  138nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50118577((2,4-Dimethyl-azetidin-1-yl)-(7-methyl-4,6,6a,7,8,...)
Affinity DataKi:  140nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50027065(12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergota...)
Affinity DataKi:  155nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50582603(CHEMBL5091373)
Affinity DataKi:  180nMAssay Description:Binding affinity to 5-HT1ER (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM31016(SMR000067014 | 2-(3-piperidinyl)-1,3-benzothiazole...)
Affinity DataEC50:  186nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM31030(MLS000045807 | cid_3245407 | SMR000028204 | 2-meth...)
Affinity DataEC50:  194nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  194nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
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