PMID

Data

Article Title

Organization

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.

Glaxosmithkline

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain"C-region".

Sandoz Institute For Medical Research

Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond"B-region".

Sandoz Institute For Medical Research

N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.

Seoul National University

N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.

Seoul National University

Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.

Sookmyung Women'S University

Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.

Seoul National University

Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.

Seoul National University

Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.

Shionogi

Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.

Shionogi

Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.

Renovis

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist.

Raqualia Pharma

Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.

Glaxosmithkline

Modulation of TRPV4 and BKCa for treatment of brain diseases.

Kunming University of Science and Technology

Cannabitwinol, a Dimeric Phytocannabinoid from Hemp,

University of Naples Federico Ii

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

National Research Council

Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit.

Astellas Pharma

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

TBA

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).

Glaxosmithkline

Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.

Sandoz Institute For Medical Research

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

Universit£

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

University of Eastern Piedmont

Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.

Shionogi