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Synthesis and biological evaluation of novel hydroxybenzaldehyde-based kojic acid analogues as inhibitors of mushroom tyrosinase.

Hunan University of Science and Technology

Characterization of the action of tyrosinase on resorcinols.

University of Murcia

Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors.

Zhejiang Gongshang University

N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459.

University of Rhode Island

Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors.

East China University of Science and Technology

Identification of six new lupane-type triterpenoids from Acanthopanax koreanum leaves and their tyrosinase inhibitory activities.

Catholic University of Daegu

One-pot green synthesis of 1,3,5-triarylpentane-1,5-dione and triarylmethane derivatives as a new class of tyrosinase inhibitors.

Jiangnan University

Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.

Gyeongsang National University

Inhibitory kinetics of novel 2,3-dihydro-1H-inden-1-one chalcone-like derivatives on mushroom tyrosinase.

University of Technology Sydney

Design and synthesis of aloe-emodin derivatives as potent anti-tyrosinase, antibacterial and anti-inflammatory agents.

Shaoyang University

Synthesis of novel compounds containing morpholine and 5(4H)-oxazolone rings as potent tyrosinase inhibitors.

Payame Noor University (Pnu)

Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.

University of Technology Sydney

Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase.

Kongju National University

Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).

Kyoto Pharmaceutical University

Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: from potent activators to highly efficient inhibitors.

Sun Yat-Sen University

Azachalcones: a new class of potent polyphenol oxidase inhibitors.

University of Technology Sydney

Rational design, synthesis and structure-activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors.

Sun Yat-Sen University

Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry.

Dongguk University-Seoul

Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.

Sungkyunkwan University

Effect of p-aminophenols on tyrosinase activity.

Hoshi University

Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.

Institute For Theoretical Medicine

Anti-tyrosinase, antioxidant, and antibacterial activities of novel 5-hydroxy-4-acetyl-2,3-dihydronaphtho[1,2-b]furans.

Yeungnam University

Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.

Solapur University

Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors.

Universit£

(-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant.

Kaohsiung Medical University

Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.

Sun Yat-Sen University

Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.

Sun Yat-Sen University

Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.

Mayoly Spindler

1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.

Sun Yat-Sen University

Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays.

Central University of Las Villas

2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis.

Fudan University

Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity.

Jeju National University

Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis.

Kyung Hee University Skin Biotechnology Center

Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.

Chungnam National University

Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase.

Universit£

Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung.

Institute of Medicinal Plant Development

New halogenated phenylcoumarins as tyrosinase inhibitors.

Universidad De Santiago De Compostela

Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.

Kinki University

Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors.

Shaoyang University

Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells.

Pusan National University

Prenylated flavanones with anti-tyrosinase activity from Dalea boliviana.

Universidad Nacional De Co£?Rdoba

Benzyl benzoates: New phlorizin analogs as mushroom tyrosinase inhibitors.

Sun Yat-Sen University

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

University of California

Changes in flavonoid content and tyrosinase inhibitory activity in kenaf leaf extract after far-infrared treatment.

Amorepacific

A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol.

University of Tokushima

Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.

Institute For Theoretical Medicine

Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.

Amorepacific

Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors.

Jinan University

Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents.

Solapur University

A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.

Pusan National University

Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.

Hoshi University

New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

King Saud University

Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors.

University Putra Malaysia

Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.

Department of Functional Crop

Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.

Chungnam National University

Asymmetric syntheses of daedalin A and quercinol and their tyrosinase inhibitory activity.

Shinshu University

Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.

Kyoto Pharmaceutical University

Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.

Kyoto Pharmaceutical University

Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.

Sun Yat-Sen University

Kojic acid-amino acid conjugates as tyrosinase inhibitors.

Seoul National University

Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.

Sun Yat-Sen University

Antityrosinase and Antioxidant Effects of ent-Kaurane Diterpenes from Leaves of Broussonetia papyrifera.

Tajen University

Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.

National Taiwan University

Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety.

Amorepacific

PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.

Università

Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki.

Graduate School of Gyeongsang National University

Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives.

Institute of Science and Technology

Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.

Sun Yat-Sen University

Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton.

Utsunomiya University

A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.

Sun Yat-Sen University

Pyronane monoterpenoids from the fruit of Gardenia jasminoides.

Chungnam National University

Complex sesquiterpenoids with tyrosinase inhibitory activity from the leaves of Chloranthus tianmushanensis.

Zhejiang University

Antityrosinase principles and constituents of the petals of Crocus sativus.

National Cheng Kung University

Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.

National Cheng Kung University

A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus.

Chulalongkorn University

Discovery of small-molecule inhibitors of tyrosinase.

University of Texas Southwestern Medical Center

Enhanced substituted resorcinol hydrophobicity augments tyrosinase inhibition potency.

Migal - Galilee Technology Center

Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

Hokkaido University

Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products.

Dhc

Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus bisporus) tyrosinase.

Xiamen University

TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-based linear indices.

Central University of Las Villas

Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.

Pusan National University

Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.

Chulalongkorn University

N-Benzylbenzamides: a new class of potent tyrosinase inhibitors.

Seoul National University

Kojic acid-natural product conjugates as mushroom tyrosinase inhibitors.

Mazandaran University of Medical Sciences

Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies.

Kongju National University

Concise Modular Synthesis of Thalassotalic Acids A-C.

TBA

2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism.

Jiangxi Normal University

Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo.

Chinese Academy of Sciences

Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors.

Hinoki Shinyaku

Inhibitors of Melanogenesis: An Updated Review.

University of Bonn

Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.

Nicolaus Copernicus University

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities.

Universiti Kuala Lumpur

Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).

Gyeongsang National University

Synthesis of N-hydroxycinnamoyl amide derivatives and evaluation of their anti-oxidative and anti-tyrosinase activities.

Beijing Technology and Business University

Veratric acid derivatives containing benzylidene-hydrazine moieties as promising tyrosinase inhibitors and free radical scavengers.

Shiraz University of Medical Sciences

Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies.

Universidad Nacional De C£Rdoba

Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.

Seoul National University of Science and Technology

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.

Polo Universitario Ss. Annunziata

Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination.

Nicolaus Copernicus University

Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.

The University of Queensland (Uq)

Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in ?-MSH-stimulated B16F10 melanoma cells.

Pusan National University

De Novo Molecular Design of a Novel Octapeptide That Inhibits In Vivo Melanogenesis and Has Great Transdermal Ability.

Dalian University of Technology

From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical.

University of Innsbruck

Resorcinol alkyl glucosides as potent tyrosinase inhibitors.

Utsunomiya University

Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol.

Susquehanna University

Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase.

Kyungpook National University

Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors.

China National Analytical Center (Guangzhou)

Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.

Hungkuang University

Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.

Gyeongsang National University

Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides.

Tokyo University of Agriculture and Technology

Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.

Kinki University

De novo tyrosinase inhibitor: 4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556).

Pusan National University

Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase.

Bahirji Smarak Mahavidyalaya

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.

Payame Noor University

Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.

Sun Yat-Sen University

Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant.

Seoul National University

Synthesis and antityrosinase activities of alkyl 3,4-dihydroxybenzoates.

Xiamen University

Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.

University of California

Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors.

Pusan National University

Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors.

University of Athens

Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.

Catholic University of C£Rdoba

Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.

Pusan National University

Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.

Hanyang University

Depigmenting activity of new kojic acid derivative obtained as a side product in the synthesis of cinnamate of kojic acid.

Hanyang University

Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.

Amorepacific Corporation R&D Center

Current progress on antioxidants incorporating the pyrazole core.

University of Aveiro

Recent advances (2015-2016) in anticancer hybrids.

University of Kwazulu Natal

The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-?-phenyl-?, ?-unsaturated carbonyl scaffold.

Pusan National University

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.

Universit�

Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers.

Quaid-I-Azam University

Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase.

University of Pretoria

Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors.

Sun Yat-Sen University

Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.

Abbottabad University of Science and Technology

Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.

The University of Tokyo