97 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Riken Center For Sustainable Resource Science
CoMFA and CoMSIA analysis of ACE-inhibitory, antimicrobial and bitter-tasting peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tianjin University
Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Department of Chemistry
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-ß hydrolysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Lille
Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Michigan
Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Washington University
Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetyls![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetyls![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synopsis of some recent tactical application of bioisosteres in drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research and Development
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universite£
Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Aarhus University
Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wroclaw University of Technology
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dipartimento Di Chimica
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University Institute of Pathology
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Mixture-based synthetic combinatorial libraries.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Torrey Pines Institute For Molecular Studies
New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Paris
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Calgary
Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Rorer Central Research
Angiotensin converting enzyme inhibitors: spirapril and related compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Schering-Plough
Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Wisconsin-Madison
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tanabe Seiyaku
Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Conformational analysis and active site modelling of angiotensin-converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptides![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cea
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Gsk Medicines Research Centre
Inhibition of Angiotensin-I-Converting Enzyme by Tetrahydroxyxanthones Isolated from Tripterospermum lanceolatum![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by tricyclic benzazepinone thiols![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
α-Mercaptoacyl dipeptides that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis of 6-amino-5-oxo-7-phenyl-1,4-oxazepines as conformationally constrained gauche (−) dipeptide mimetics![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Santen Pharmaceutical
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Athens
Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Leipzig
Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Santen Pharmaceutical
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Cape Town
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kingston University
Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Cape Town
Structure-activity relationship study between Ornithyl-Proline and Lysyl-Proline based tripeptidomimics as angiotensin-converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Genomics and Integrative Biology
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chinese Academy of Sciences
Bradykinin-Potentiating Peptide-Paclitaxel Conjugate Directed at Ectopically Expressed Angiotensin-Converting Enzyme in Triple-Negative Breast Cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hong Kong Baptist University
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Cape Town
Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
British Biotech Pharmaceuticals
2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Roche Pharma Research and Early Development
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bath
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shionogi
Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ciba-Geigy
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Paris
Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
E£Tv£S Lor£Nd University
Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Schering-Plough Research Institute
PRO_LIGAND: an approach to de novo molecular design. 2. Design of novel molecules from molecular field analysis (MFA) models and pharmacophores.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Proteus Molecular Design
The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Mrc Laboratory of Molecular Biology, Hills Road, Cambridge, Cb2 2Qh
Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bath
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Csir-National Chemical Laboratory
Metabolomics-Guided Discovery of Microginin Peptides from Cultures of the Cyanobacterium Microcystis aeruginosa.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of North Carolina Wilmington
Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vit University
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ranbaxy Laboratories