BDBM28802 2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-fluorophenyl)methyl](methoxycarbonyl)amino}acetic acid::BMS-711939
SMILES COC(=O)N(CC(O)=O)Cc1cc(OCc2nc(oc2C)-c2ccc(Cl)cc2)ccc1F
InChI Key InChIKey=OPHWZEQODBXRCZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 28802
Affinity DataIC50: 97nM EC50: 4nMpH: 8.0 T: 22°CAssay Description:For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl...More data for this Ligand-Target Pair
Affinity DataEC50: 4.51E+3nMAssay Description:Agonist activity at Gal4-tagged human PPAR-gamma expressed in HEK cells by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 145nMAssay Description:EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 123nMAssay Description:EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at full length human PPAR-alpha transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.61E+3nMAssay Description:Agonist activity at full length human PPAR-gamma transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 144nMAssay Description:Agonist activity at mouse PPAR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 123nMAssay Description:Agonist activity at rat PPAR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at Gal4-tagged human PPAR-alpha expressed in HEK cells by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human PPAR-delta by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human LXR by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human GR by transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha/RXR-beta/RXR-gamma(Human)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human RXR by transactivation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of CYP2C19 in human TC5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of CYP2C9 in human TC5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of CYP2D6 in human TC5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of CYP3A4 in human TC5 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by flux-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: >9.84E+4nMAssay Description:Binding affinity to human GST-tagged PPAR-gamma LBD expressed in Escherichia coli BL21 after 30 mins in presence of fluorescein ligand FLA-A by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:Binding affinity to human GST-tagged PPAR-alpha LBD expressed in Escherichia coli BL21 (DE3) PlysS after 30 mins in presence of fluorescein ligand FL...More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nM EC50: 4.51E+3nMpH: 8.0 T: 22°CAssay Description:For PPARgamma, the percentage inhibition was calculated relative to rosiglitazone, which was used as the active site-specific competitive binder. Flu...More data for this Ligand-Target Pair