BDBM23223 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde::CHEMBL51483::Gossypol::Gossypol (C9)::Gossypol, 4::Pogosin::Tash 1::US9115061, Gossypol::cid_3503
SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O
InChI Key InChIKey=QBKSWRVVCFFDOT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 46 hits for monomerid = 23223
Affinity DataIC50: 5.80E+3nMAssay Description:MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...More data for this Ligand-Target Pair
Affinity DataIC50: 2.55E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4 gamma 1(Homo sapiens (Human))
Emory University
Curated by PubChem BioAssay
Emory University
Curated by PubChem BioAssay
Affinity DataIC50: 6.40E+4nMAssay Description:Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.52E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
Affinity DataIC50: 3.97E+3nMAssay Description:Enzyme assay using recombinant pfLDH and mLDH (bovine heart).More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Enzyme assay using recombinant pfLDH and mLDH (bovine heart).More data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed at 100 µL total volume in triplicate and monitored for 60 minutes at room temperature in a 96-well plate format in HEPES Bu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.72E+3nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes) and purified ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Ku Leuven
Curated by ChEMBL
Ku Leuven
Curated by ChEMBL
Affinity DataIC50: 4.57E+3nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Ku Leuven
Curated by ChEMBL
Ku Leuven
Curated by ChEMBL
Affinity DataIC50: 3.24E+3nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Binding affinity to human Bcl2 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human purified MPG pre-incubated with compound for 10 mins followed by addition of 1,N6 ethenoadenine containing 32P-labeled duplex oli...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of Escherichia coli AmpC beta lactamase using relaxed assay conditions in presence of 0.00001% Triton X-100 detergentMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+4nMAssay Description:Aggregate based-inhibition of Escherichia coli AmpC beta lactamase using stringent assay conditions in presence of 0.01% Triton X-100 detergentMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory concentration against Bcl-xlMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KSPMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 856nMAssay Description:Inhibition of FAM-Bid binding to human MCL1 expressed in Escherichia coli BL21 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of FAM-Bid binding to human BCL2 expressed in Escherichia coli BL21 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of Bcl-2 (unknown origin) after 15 hrs by FRET methodMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of human recombinant Eg5 ATPase activity expressed in Escherichia coli after 30 mins by malachite green-based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of FAM-Bid peptide binding to Mcl1 (unknown origin) expressed in Escherichia coli BL21 by fluorescence polarization-based binding assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of biotin-Bim peptide binding to Mcl1 (unknown origin) expressed in Escherichia coli BL21 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of biotinylated Bim peptide binding to His-tagged Bcl-2 (unknown origin) preincubated for 1 hr followed by biotinylated Bim peptide additi...More data for this Ligand-Target Pair
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
TargetThiosulfate sulfurtransferase(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)
France
Curated by ChEMBL
France
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of Pseudomonas aeruginosa IMPDH using IMP as substrate in the presence of NAD+ incubated for 70 secsMore data for this Ligand-Target Pair
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 u...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with high 200 uM 2OG...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 u...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using high 10 uM hFX-CP as substrate mixture with 10 uM 2OG...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Wuhan University School Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.52E+3nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Displacement of biotinylated Bim peptide from Bcl-2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.53E+3nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...More data for this Ligand-Target Pair
Affinity DataIC50: 2.03E+3nMAssay Description:MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...More data for this Ligand-Target Pair
Affinity DataIC50: 7.16E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of radioligand [3H]GR-65630.More data for this Ligand-Target Pair
Affinity DataIC50: 2.64E+3nMpH: 7.0 T: 2°CAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair
Affinity DataIC50: 9.54E+3nMpH: 7.0 T: 2°CAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair