BDBM50005410 CHEMBL139197::CHEMBL2137199

SMILES OC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=KVHKWAZUPPBMLL-UHFFFAOYSA-N

Data  1 KI  11 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50005410   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  420nMAssay Description:Antagonist activity at full-length RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  3.54E+3nMAssay Description:Antagonist activity at human His6-tagged RORgamma ligand binding domain (262 to 507 aa) assessed as inhibition of SRC1-4 co-activator peptide recruit...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]T0901317 from human RoRc expressed in HepG2 cells by scintillation proximity binding assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50: >2.00E+4nMAssay Description:Inverse agonist activity at human GAL4-fused RORalpha LBD transfected in 293T cell measured after 24 hrs by dual luciferase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  110nMAssay Description:Inhibition of Gal4-RORgamma-LBD (180 to 507 residues) (unknown origin) expressed in HEK293T cells after 24 hrs by dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  320nMAssay Description:Inhibition of human GAL4-fused RORgamma transfected in HEK293 cells co-transfected with G6Pase by luciferase reporter assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50: >2.00E+4nMAssay Description:Inverse agonist activity at human GAL4-fused FXR LBD transfected in 293T cell measured after 24 hrs by dual luciferase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50: >2.00E+4nMAssay Description:Inverse agonist activity at human GAL4-fused LXRalpha LBD transfected in 293T cell measured after 24 hrs by dual luciferase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-beta(Homo sapiens (Human))TBA
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50: >2.00E+4nMAssay Description:Inverse agonist activity at human GAL4-fused RORbeta LBD transfected in 293T cell measured after 24 hrs by dual luciferase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  430nMAssay Description:Antagonist activity at Gal4-fused RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50005410(CHEMBL139197 | CHEMBL2137199)
Affinity DataIC50:  910nMAssay Description:Displacement of N-terminal biotinylated SRC1-4 coactivator peptide from N-terminal His6-fused human RORgamma-LBD (262 to 507 residues) expressed in E...More data for this Ligand-Target Pair