BDBM50188062 1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)piperazine::CHEMBL375131

SMILES FC(F)(F)Oc1ccccc1CC(N1CCNCC1)c1ccccc1

InChI Key InChIKey=GYZLMHZBYPNULH-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50188062   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataIC50:  1.09E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataIC50:  38nMAssay Description:Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed