BDBM8885 (1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one::17beta-Hydroxyandrost-4-en-3-one::Testosterone::Testosterone, 1::US9682960, Testosterone
SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
InChI Key InChIKey=MUMGGOZAMZWBJJ-DYKIIFRCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 37 hits for monomerid = 8885
Affinity DataKi: 3.20nM IC50: 4.70nMAssay Description:A series of dilutions of the compounds were prepared with 10% DMSO in HDAC assay buffer, and 5uL of the dilution was added to a 50uL reaction so that...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human ERbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibitory activity against ARMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human androgen receptor expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSex hormone-binding globulin(Homo sapiens (Human))
University Of British Columbia
Curated by ChEMBL
University Of British Columbia
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]DHT from human SHBGMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human recombinant ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human recombinant ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity at human recombinant ERbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Binding affinity at ARMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Displacement of [3H]Mibolerone from rat recombinant androgen receptor expressed in Escherichia coli after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.09E+3nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Binding affinity to androgen receptor by fluorescence binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.68E+4nMAssay Description:Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Yanbian University College Of Pharmacy
Curated by ChEMBL
Yanbian University College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of CYP3A4T (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Yanbian University College Of Pharmacy
Curated by ChEMBL
Yanbian University College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of CYP3A4T in human liver microsomes incubated for 15 to 40 mins in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human ERalphaMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 3(Mus musculus)
University Of Kuopio
Curated by ChEMBL
University Of Kuopio
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory concentration against mammalian m-constitutive androstane receptor (mCAR) activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Yanbian University College Of Pharmacy
Curated by ChEMBL
Yanbian University College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity for Cytochrome P450 3A4; Range = 1-10 uMMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Displacement of [3H]R1881 from pSG5-tagged human androgen receptor expressed in COS1 cells assessed as relative binding inhibitionMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity against pSG5-tagged human androgen receptor expressed in COS1 cells assessed as reduction in receptor-mediated transcriptional ac...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Androgen binding is measured using the hydroxylapatite (HAP) assay. In brief, the radioactive steroid [3H]R1881 solubilized in ethanol is diluted wit...More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 2B10(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 2B7(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 1.65E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1-6(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 4.30E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
Affinity DataIC50: 5.35E+4nMAssay Description:AChE and BChE inhibiting activities were measured in vitro by a modified spectrophotometric method previously developed by Ellman et. al.More data for this Ligand-Target Pair
Affinity DataIC50: 4.57nMAssay Description:Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation ass...More data for this Ligand-Target Pair