Compile Data Set for Download or QSAR
Report error Found 264 Enz. Inhib. hit(s) with Target = 'Asialoglycoprotein receptor 1'
TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660609(US20240092819, Compound 262)
Affinity DataIC50: 48nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660608(US20240092819, Compound 261)
Affinity DataIC50: 58nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50074090(Galactoside analogue | CHEMBL2368210)
Affinity DataKi:  93nMAssay Description:Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAsialoglycoprotein receptor 1(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50074091(Galactoside analogue | CHEMBL2368208)
Affinity DataKi:  93nMAssay Description:Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAsialoglycoprotein receptor 1(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50074089(TG(20)C-Galactoside analogue | CHEMBL2368207)
Affinity DataKi:  200nMAssay Description:Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660614(US20240092819, Compound 268)
Affinity DataIC50: 335nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660613(US20240092819, Compound 267)
Affinity DataIC50: 563nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660615(US20240092819, Compound 269)
Affinity DataIC50: 598nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408867(US10376531, Compound 27 | US10813942, Compound 27)
Affinity DataKd:  700nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408867(US10376531, Compound 27 | US10813942, Compound 27)
Affinity DataKd:  1.10E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408863(US10376531, Compound 24 | US10813942, Compound 24)
Affinity DataKd:  1.10E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408868(US10376531, Compound 28 | US10813942, Compound 28)
Affinity DataKd:  1.20E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408863(US10376531, Compound 24 | US10813942, Compound 24)
Affinity DataKd:  1.40E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660610(US20240092819, Compound 263)
Affinity DataIC50: 1.64E+3nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408868(US10376531, Compound 28 | US10813942, Compound 28)
Affinity DataKd:  2.00E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408858(US10376531, Compound 20 | US10813942, Compound 20)
Affinity DataKd:  2.18E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408862(US10376531, Compound 25 | US10813942, Compound 25)
Affinity DataKd:  2.20E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408860(US10376531, Compound 21 | US10813942, Compound 21)
Affinity DataKd:  2.60E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408856(US10376531, Compound 18 | US10813942, Compound 18)
Affinity DataKd:  3.00E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408862(US10376531, Compound 25 | US10813942, Compound 25)
Affinity DataKd:  3.10E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408856(US10376531, Compound 18 | US10813942, Compound 18)
Affinity DataKd:  3.10E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408859(US10376531, Compound 19 | US10813942, Compound 19)
Affinity DataKd:  3.30E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408860(US10376531, Compound 21 | US10813942, Compound 21)
Affinity DataKd:  3.40E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408858(US10376531, Compound 20 | US10813942, Compound 20)
Affinity DataKd:  3.40E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408857(US10376531, Compound 17 | US10813942, Compound 17)
Affinity DataKd:  3.80E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408859(US10376531, Compound 19 | US10813942, Compound 19)
Affinity DataKd:  4.70E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408857(US10376531, Compound 17 | US10813942, Compound 17)
Affinity DataKd:  5.30E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408861(US10376531, Compound 22 | US10813942, Compound 22)
Affinity DataKd:  5.50E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408861(US10376531, Compound 22 | US10813942, Compound 22)
Affinity DataKd:  6.50E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408865(US10376531, Compound 29 | US10813942, Compound 29)
Affinity DataKd:  6.90E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408853(US10376531, Compound 3 | US10813942, Compound 3)
Affinity DataKd:  7.18E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408853(US10376531, Compound 3 | US10813942, Compound 3)
Affinity DataKd:  7.18E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408855(US10376531, Compound 1 | US10813942, Compound 1)
Affinity DataKd:  9.00E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408855(US10376531, Compound 1 | US10813942, Compound 1)
Affinity DataKd:  9.00E+3nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656245(US20240072809, Compound A333)
Affinity DataKd: >1.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656277(US20240072809, Compound A370)
Affinity DataKd: >1.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408865(US10376531, Compound 29 | US10813942, Compound 29)
Affinity DataKd:  1.02E+4nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408869(US10376531, Compound 31 | US10813942, Compound 31)
Affinity DataKd:  1.23E+4nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM408869(US10376531, Compound 31 | US10813942, Compound 31)
Affinity DataKd:  1.37E+4nMAssay Description:All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660611(US20240092819, Compound 264)
Affinity DataIC50: 1.44E+4nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Rat)
Sanofi

US Patent
LigandPNGBDBM660612(US20240092819, Compound 265)
Affinity DataIC50: 1.62E+4nMAssay Description:The assay was performed in 384-well microplates (GREINER bio-one, 781076). Membrane prepared from Wistar rat liver was used as a source of ASGPR and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656268(US20240072809, Compound A361)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656264(US20240072809, Compound A356)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656276(US20240072809, Compound A369)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656275(US20240072809, Compound A368)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656272(US20240072809, Compound A365)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656189(US20240072809, Compound A157)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656187(US20240072809, Compound A149)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656186(US20240072809, Compound A148)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

TargetAsialoglycoprotein receptor 1(Human)
Pfizer

US Patent
LigandPNGBDBM656260(US20240072809, Compound A351)
Affinity DataKd: >2.00E+4nMAssay Description:The dissociation constants (KD) of compounds described herein to the ASGP receptor are measured in SPR experiments using a Biacore 8K instrument (GE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
US Patent

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