Compile Data Set for Download or QSAR
Report error Found 2853 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 2B'
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396904BDBM396904(US9981950, Example 113B)
Affinity DataIC50: 0.480nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 398608BDBM398608(US10323021, Example 114)
Affinity DataIC50: 0.510nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396901BDBM396901(US9981950, Example 110)
Affinity DataIC50: 0.520nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124914BDBM50124914(N-(3,5-Dichloro-benzyl)-4-trifluoromethoxy-benzami...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50009307BDBM50009307(Di-o-tolylguanidine | DITOLYLGUANIDINE)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ifenprodil from GluN2B in mouse LTK cells assessed as inhibition constant measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269772BDBM50269772(CHEMBL4094573)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269769BDBM50269769(CHEMBL4086848)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396903BDBM396903(US9981950, Example 113A)
Affinity DataIC50: 0.650nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124885BDBM50124885(N-(2-methoxybenzyl)cinnamamidine | (E)-N-(2-Methox...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50557186BDBM50557186(CHEMBL493054)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ifenprodil from GluN2B in mouse LTK cells assessed as inhibition constant measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505140BDBM50505140(CHEMBL4526884)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269780BDBM50269780(CHEMBL4095807)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269752BDBM50269752(CHEMBL4078903)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124885BDBM50124885(N-(2-methoxybenzyl)cinnamamidine | (E)-N-(2-Methox...)
Affinity DataKd:  1nMAssay Description:Binding affinity towards human NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505124BDBM50505124(CHEMBL4534333)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50204883BDBM50204883((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50641130BDBM50641130(CHEMBL5569595)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]ifenprodil from rat GluN2B assessed as inhibition constant measured after 120 mins by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124909BDBM50124909(N-(3,5-Dimethyl-benzyl)-4-trifluoromethoxy-benzami...)
Affinity DataKi:  1.20nMAssay Description:Displacement of NMDA receptor-specific [3H]ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50204865BDBM50204865([4-(4-fluoro-benzyl)-piperidin-1-yl)]-(6-hydroxy-1...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50641134BDBM50641134(CHEMBL5595448)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ifenprodil from rat GluN2B assessed as inhibition constant measured after 120 mins by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50641105BDBM50641105(CHEMBL5574644)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ifenprodil from rat GluN2B assessed as inhibition constant measured after 120 mins by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 276115BDBM276115(2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of 3-(3H) 1-(azetidin-1-yl)-2-(6- (4-fluoro-3-methyl-phenyl)pyrrolo-(3,2-6) pyridin-1yl)ethanone from GluN2B receptor in rat cortical me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50204868BDBM50204868(N-[2-(4-benzyl-piperidin-1-carbonyl)-3H-benzimidaz...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198665BDBM198665(US9221796, 2b)
Affinity DataKi:  1.40nM ΔG°:  -54.8kJ/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198694BDBM198694(US9221796, 23b)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198694BDBM198694(US9221796, 23b)
Affinity DataKi:  1.40nM ΔG°:  -54.8kJ/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198665BDBM198665(US9221796, 2b)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198687BDBM198687(US9221796, 18b)
Affinity DataKi:  1.5nM ΔG°:  -54.6kJ/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198681BDBM198681(US9221796, 13b)
Affinity DataKi:  1.60nM ΔG°:  -54.4kJ/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499215BDBM50499215(CHEMBL3735947)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ifenprodil from Glun2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396889BDBM396889(US9981950, Example 96)
Affinity DataIC50: 1.60nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50203305BDBM50203305(benzyl 4-[(pyridin-4-ylamino)methyl]piperidine-1-c...)
Affinity DataEC50:  1.60nMAssay Description:Antagonist activity at human NR2B expressed in Ltk- cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499215BDBM50499215(CHEMBL3735947)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ifenprodil from human recombinant GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198685BDBM198685(US9221796, 17)
Affinity DataKi:  1.60nM ΔG°:  -54.4kJ/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396848BDBM396848(US9981950, Example 55)
Affinity DataIC50: 1.64nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50204882BDBM50204882([4-(4-chloro-phenoxy)-piperidin-1-yl]-(6-hydroxy-1...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396863BDBM396863(US9981950, Example 70)
Affinity DataIC50: 1.84nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50641119BDBM50641119(CHEMBL5563730)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ifenprodil from rat GluN2B assessed as inhibition constant measured after 120 mins by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396893BDBM396893(US9981950, Example 100)
Affinity DataIC50: 1.90nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50385168BDBM50385168(CHEMBL2036514)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain olfactory tubercleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212688BDBM50212688(2-(3,5-dimethyl-benzyl)-5-trifluoromethoxy-2,3-dih...)
Affinity DataKi:  2nMAssay Description:Binding affinity to NMDA NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 409275BDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 2nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 198835BDBM198835(US9221796, 116)
Affinity DataKi:  2nM ΔG°:  -53.8kJ/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269783BDBM50269783(CHEMBL4059534)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Westf£Lische Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505122BDBM50505122(CHEMBL4583880)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50539161BDBM50539161(CHEMBL4637295)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]ifenprodil from human recombinant GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50124908BDBM50124908(N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidin...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]ifenprodil from Wistar rat GluN2B receptor after 2 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 396902BDBM396902(US9981950, Example 111)
Affinity DataIC50: 2.13nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212685BDBM50212685(2-benzofuran-7-ylmethyl-5-trifluoromethoxy-2,3-dih...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to NMDA NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50204899BDBM50204899((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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