Compile Data Set for Download or QSAR
Report error Found 441 Enz. Inhib. hit(s) with Target = 'Glycine receptor subunit alpha-1'
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM198936(US9676786, example 5)
Affinity DataEC50:  0.000160nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50459971(CHEMBL4227144)
Affinity DataEC50:  0.000160nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM199088(US9676786, example 6)
Affinity DataEC50:  0.00120nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM199088(US9676786, example 6)
Affinity DataEC50:  0.00120nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50459968(CHEMBL4228372)
Affinity DataEC50:  0.0600nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM198933(US9676786, example 2)
Affinity DataEC50:  0.0600nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM198934(US9676786, example 3)
Affinity DataEC50:  0.430nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50459970(CHEMBL4227297)
Affinity DataEC50:  0.430nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50304335(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Affinity DataIC50: 1.07nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50304334(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-tropane | ...)
Affinity DataIC50: 10.2nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50304335(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Affinity DataIC50: 11.5nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50232884(CHEMBL4060962)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the later state of compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  32nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50304335(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Affinity DataIC50: 33.9nMAssay Description:Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415201(CHEMBL611364)
Affinity DataIC50: 33.9nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232885(CHEMBL4089150)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415204(CHEMBL596443)
Affinity DataIC50: 41.7nMAssay Description:Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50232889(CHEMBL4103909)
Affinity DataIC50: 43nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50232896(CHEMBL4079657)
Affinity DataIC50: 46nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232896(CHEMBL4079657)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced currents by whole-ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415205(CHEMBL595797)
Affinity DataIC50: 50.1nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced whole cell currents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232889(CHEMBL4103909)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232889(CHEMBL4103909)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50570357(CHEMBL4865147)
Affinity DataIC50: 55nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the later state of compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50232890(CHEMBL4102677)
Affinity DataIC50: 56nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced whole cell curre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415208(CHEMBL608418)
Affinity DataIC50: 58.9nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232889(CHEMBL4103909)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50225707(CHEBI:28973 | Strychnine)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced currents by whol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415210(CHEMBL608417)
Affinity DataIC50: 60.3nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232888(CHEMBL4096857)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50570358(CHEMBL4855686)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the later state of compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50304335(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)
Affinity DataIC50: 70.8nMAssay Description:Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415211(CHEMBL595791)
Affinity DataIC50: 72.4nMAssay Description:Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232890(CHEMBL4102677)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232884(CHEMBL4060962)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232884(CHEMBL4060962)
Affinity DataIC50: 77nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50232884(CHEMBL4060962)
Affinity DataIC50: 78nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Rat)
Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50415206(CHEMBL596257)
Affinity DataIC50: 79.4nMAssay Description:Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50232885(CHEMBL4089150)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
The University of Liverpool

US Patent
LigandPNGBDBM50570357(CHEMBL4865147)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
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