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Report error Found 344 Enz. Inhib. hit(s) with Target = 'Lanosterol 14-alpha demethylase'
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276215(CHEMBL4128885)
Affinity DataKd:  10nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Rat)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50161586(4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylme...)
Affinity DataKi:  11nMAssay Description:Apparent Ki for rat Lanosterol 14-alpha demethylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276213(CHEMBL4127493)
Affinity DataKd:  13nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276214(CHEMBL4129161)
Affinity DataKd:  13nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50505764(CHEMBL4461447)
Affinity DataKd:  20nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215880(CHEMBL52311 | Ro-092364)
Affinity DataIC50: 22.5nMAssay Description:In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKi:  25nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276218(CHEMBL4128615)
Affinity DataKd:  25nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataKd:  26nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215878(CHEMBL54768 | Ro-092056)
Affinity DataIC50: 28.1nMAssay Description:In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215878(CHEMBL54768 | Ro-092056)
Affinity DataIC50: 28.1nMAssay Description:In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article

TargetLanosterol 14-alpha demethylase(Rat)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylme...)
Affinity DataKi:  37nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50044425(4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylme...)
Affinity DataKi:  40nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50044425(4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylme...)
Affinity DataKi:  40.4nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50638513(CHEMBL5555392)
Affinity DataIC50: 43nMAssay Description:Inhibition of Candida albicans ATCC SC5314 CYP51 using lanosterol as substrate incubated for 30 mins by HPLC assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetLanosterol 14-alpha demethylase(Rat)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 47nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM31773(ECONAZOLE | cid_68589 | Pevaryl | Gyno-pevaryl | E...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215879(CHEMBL415943 | Ro-092435)
Affinity DataIC50: 56.3nMAssay Description:In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50505761(CHEMBL4277680)
Affinity DataKd:  60nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKi:  64nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Rat)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKi:  65nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  69nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215883(CHEMBL53214 | Ro-092182)
Affinity DataIC50: 73.3nMAssay Description:In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50593137(CHEMBL5187700)
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP51 in Candida albicans SC5314 using Eburicol as substrate preincubated for 20 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50181473(CHEMBL1397 | 4-(4-(4-(4-(((5R)-5-((1H-1,2,4-triazo...)
Affinity DataKd:  81nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215876(CHEMBL53213 | Ro-092173)
Affinity DataIC50: 83nMAssay Description:In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50011478(ITRAZOLE)
Affinity DataIC50: 85nMAssay Description:In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50215882(CHEMBL298394 | Ro-092183)
Affinity DataIC50: 86.8nMAssay Description:In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50505766(CHEMBL4522116)
Affinity DataKd:  90nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465948(CHEMBL3629567)
Affinity DataKd:  90nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50469749(CHEMBL349069 | Ro-092127)
Affinity DataIC50: 90.3nMAssay Description:In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article

TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276219(CHEMBL4126063)
Affinity DataKd:  95nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataIC50: 98nMAssay Description:Inhibition of candida albicans CYP51 14alpha demethylase activity incubated for 30 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628755(US20230339890, Compound 128)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628756(Preparation of 2-(3,4-Dichlorophenyl)-N-[(2R)-2-Hy...)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628757(US20230339890, Compound 31)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628761(US20230339890, Compound 105)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628763(Preparation of N-[(2S)-2-Hydroxy-2-(3-Pyridyl)Ethy...)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628879(US20230339890, Compound 147)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628867(US20230339890, Compound 145 | US20230339890, Compo...)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628733(US20230339890, Compound 77)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628735(US20230339890, Compound 125)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628876(US20230339890, Compound 74)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628881(Preparation of 2-[4-(Difluoromethyl)-3-Fluoro-Phen...)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628788(US20230339890, Compound 109)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628792(US20230339890, Compound 11)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628803(US20230339890, Compound 135)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628797(US20230339890, Compound 134)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628775(US20230339890, Compound 107)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM628776(US20230339890, Compound 131)
Affinity DataIC50: 100nMAssay Description:Method: Recombinant human CYP51A1 (lanosterol-14a-demethylase) enzyme was coexpressed with CYP reductase in bacterial membranes and the fluorescent s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

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