Compile Data Set for Download or QSAR
Report error Found 119 Enz. Inhib. hit(s) with Target = 'Large neutral amino acids transporter small subunit 1'
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50: 60nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50: 60nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025839(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Affinity DataKi:  79nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025839(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Affinity DataKi:  200nMAssay Description:Binding affinity to LAT1 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50: 790nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50: 790nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50528545(CHEMBL4526588)
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant human LAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.19E+3nMAssay Description:Binding affinity to human SLC7A5 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319696((+/-)-2-endo-amino-bis(2-chloroethyl)-7'-aminobenz...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  2.22E+3nMAssay Description:Binding affinity to human SLC7A5 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50540285(CHEMBL4642431)
Affinity DataIC50: 3.48E+3nMAssay Description:Induction of LAT1-mediated polyamine efflux in human L3.6PL cells assessed as reduction in cell viability after 48 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319694((+/-)-2-Amino-(bis-2-chloroethyl)-5-aminoindane-2-...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50174344(CHEMBL58129)
Affinity DataIC50: 6.60E+3nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50174344(CHEMBL58129)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50174345(CHEMBL3809112)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50174345(CHEMBL3809112)
Affinity DataIC50: 7.30E+3nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025838((+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid ...)
Affinity DataKi:  7.70E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025836((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  8.50E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50174343(CHEMBL3809645)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340672(US9771316, Example 70)
Affinity DataIC50: 1.04E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319693((+/-)-2-Aminoindane-2-carboxylic acid | CHEMBL1082...)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463188(CHEMBL4248463)
Affinity DataIC50: 1.70E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50532380(CHEMBL4522605)
Affinity DataIC50: 1.82E+4nMAssay Description:Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50532380(CHEMBL4522605)
Affinity DataIC50: 1.82E+4nMAssay Description:Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50606666(CHEMBL5219332)
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of LAT1 in human MCF7 cells assessed as inhibition of leucine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM181118(US9138393, Histidine | US9144538, Histidine)
Affinity DataIC50: 2.00E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025836((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to LAT1 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319695((+/-)-2-Aminobenzo-bicyclo-[2.2.1]heptane-2'-exo-c...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463321(CHEMBL4239455)
Affinity DataIC50: 2.77E+4nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463211(CHEMBL4244215)
Affinity DataIC50: 2.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463322(CHEMBL4242544)
Affinity DataIC50: 3.24E+4nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463202(CHEMBL4241703)
Affinity DataIC50: 3.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340669(US9771316, Example 68)
Affinity DataIC50: 3.64E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340672(US9771316, Example 70)
Affinity DataIC50: 3.66E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340542(US9771316, Example 44)
Affinity DataIC50: 3.94E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM36161(D-phenylalanine)
Affinity DataIC50: 4.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025837(CHEMBL852 | 2-amino-3-[4-bis(2-chloroethyl)amino]p...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM18073(L-[2,3,4,5,6-3H]phenylalanine | (2S)-2-amino-3-phe...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340549(US9771316, Example 48)
Affinity DataIC50: 5.66E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340539(US9771316, Example 26)
Affinity DataIC50: 5.70E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340532(US9771316, Example 1)
Affinity DataIC50: 5.75E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340661(US9771316, Example 66)
Affinity DataIC50: 6.28E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340536(US9771316, Example 12)
Affinity DataIC50: 6.30E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50: 6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463208(CHEBI:16414 | L-Valine | NSC-76038 | Valine)
Affinity DataIC50: 6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319691((+/-)-2-amino-6-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463186(CHEMBL4242404)
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50463186(CHEMBL4242404)
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM340671(US9771316, Example 69)
Affinity DataIC50: 6.90E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2019
Entry Details
US Patent

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18073(L-[2,3,4,5,6-3H]phenylalanine | (2S)-2-amino-3-phe...)
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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