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Report error Found 1175 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 11'
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605782(CHEMBL5174953)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50219316(CHEMBL545353)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222627(CHEMBL356125)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222624(CHEMBL357598)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605781(CHEMBL5202475)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50473625(CHEMBL69319)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of wild type p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222629(CHEMBL142187)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605756(CHEMBL5184542)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222628(CHEMBL142697)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of LPS-stimulated p38-related TNF-alpha production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50122995(3-[2-((S)-2-Methoxy-1-methyl-ethylamino)-pyridin-4...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50122391(5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piper...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50476040(CHEMBL219796)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50122389(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50219323(CHEMBL161276)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50122996(2-Phenyl-3-[2-((S)-1-phenyl-ethylamino)-pyrimidin-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.670nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222105(CHEMBL92814)
Affinity DataIC50: 0.700nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50492380(CHEMBL2402001)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50209771(Dihydro-quinolinone | 3,4-dihydroquinolin-2(1H)-on...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of mitogen-activated protein kinase p38 at 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of LPS-stimulated p38-related IL1-beta production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605761(CHEMBL5197888)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222626(CHEMBL142289)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222619(CHEMBL343682)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50357902(CHEMBL1738839)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50215268(CHEMBL325211)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222621(CHEMBL142463)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222622(CHEMBL358108)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222096(CHEMBL92648)
Affinity DataIC50: 1.20nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50460012(CHEMBL4227523)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MAPK p38 in human THP1 cells assessed as reduction in LPS-induced TNFalpha production preincubated for 60 mins followed by LPS addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222620(CHEMBL356754)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605772(CHEMBL5208103)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222108(CHEMBL93028)
Affinity DataIC50: 1.30nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50219315(CHEMBL161477)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222094(CHEMBL96305)
Affinity DataIC50: 1.5nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50067495(2-(4-Fluoro-phenyl)-4-(3-methoxy-benzyloxy)-3-pyri...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50476039(CHEMBL219869)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50476037(CHEMBL218968)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222625(CHEMBL142050)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50222107(CHEMBL93650)
Affinity DataIC50: 1.60nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50492375(CHEMBL2401997)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252777(N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalaz...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant GST-tagged p38beta-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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