Compile Data Set for Download or QSAR
Report error Found 851 Enz. Inhib. hit(s) with Target = 'Phenylethanolamine N-methyltransferase'
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  1.55nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554691(CHEMBL4764318)
Affinity DataKi:  2.10nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3nMAssay Description:Binding affinity for phenylethanolamine N-methyl-transferase was determined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nM ΔG°:  -50.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of [3H]methyl-AdoMet binding to human phenylethanolamine N-methyl-transferase expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554692(CHEMBL4751862)
Affinity DataKi:  3.20nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554690(CHEMBL4782649)
Affinity DataKi:  3.30nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554695(CHEMBL4760727)
Affinity DataKi:  3.5nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554693(CHEMBL4800292)
Affinity DataKi:  3.80nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554689(CHEMBL4754656)
Affinity DataKi:  3.90nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50081952(((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-...)
Affinity DataKi:  4.90nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50018237(CHEMBL541538 | 6,7,8,9-Tetrahydro-3-thia-1,2,8-tri...)
Affinity DataKi:  8nMAssay Description:Binding affinity for phenylethanolamine N-methyl-transferase was determined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibitory activity against human phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibitory potency was measured against phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM14061(8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine |...)
Affinity DataKi:  10nMAssay Description:Inhibitory binding affinity for phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50100949((7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth...)
Affinity DataKi:  12nMAssay Description:Binding affinity against Human phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50077544((S)-3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataKi:  16nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50077537((7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth...)
Affinity DataKi:  17nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50174121(7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinolinef |...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50174121(7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinolinef |...)
Affinity DataKi:  17nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554685(CHEMBL4749263)
Affinity DataKi:  18nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50029108(6,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | ...)
Affinity DataKi:  20nMAssay Description:Dissociation constant(Ki) of compound was determined to measure Phenylethanolamine N-methyl-transferase inhibitory potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nM ΔG°:  -45.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50240934(3-(hydroxymethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,...)
Affinity DataKi:  28nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50240934(3-(hydroxymethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,...)
Affinity DataIC50: 28nMAssay Description:Inhibition of PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50029102(7-Chloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL1...)
Affinity DataKi:  29nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50029107(8-Chloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL1...)
Affinity DataKi:  30nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13028(CHEMBL177621 | 3-(fluoromethyl)-N-(3,3,3-trifluoro...)
Affinity DataKi:  35nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554694(CHEMBL4740168)
Affinity DataKi:  38nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13025(CHEMBL176112 | N-(4-chlorophenyl)-3-(hydroxymethyl...)
Affinity DataKi:  39nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM14060(CHEMBL26828 | 7-Iodo-1,2,3,4-tetrahydroisoquinolin...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50276413(7-isothiocyanatotetrahydroisoquinoline | CHEMBL459...)
Affinity DataKi:  40nMAssay Description:Displacement of phenylethanolamine from human PNMT by competitive inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50554681(CHEMBL4795252)
Affinity DataKi:  46nMAssay Description:Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13024(CHEMBL290890 | N-(4-chlorophenyl)-3-(fluoromethyl)...)
Affinity DataKi:  46nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50077537((7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth...)
Affinity DataKi:  47nMAssay Description:Binding affinity against Human phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50276413(7-isothiocyanatotetrahydroisoquinoline | CHEMBL459...)
Affinity DataKi:  50nMAssay Description:Binding affinity to wild type human PNMT by liquid scintillation spectrometry in presence of [3H]AdoMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50029101(5,6,7,8-Tetrachloro-1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataKi:  52nMAssay Description:Dissociation constant(Ki) of compound was determined to measure Phenylethanolamine N-methyl-transferase inhibitory potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13023(CHEMBL41647 | 3-(hydroxymethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity against human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13023(CHEMBL41647 | 3-(hydroxymethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  52nM ΔG°:  -43.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM13023(CHEMBL41647 | 3-(hydroxymethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  52nMAssay Description:In vitro binding affinity against human phenylethanolamine N-MethyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50072977(7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-...)
Affinity DataKi:  56nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50072977(7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-...)
Affinity DataKi:  56nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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