Compile Data Set for Download or QSAR
Report error Found 7231 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR'
TargetSerine/threonine-protein kinase mTOR(Mouse)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of mTOR in Tsc1 knockout mouse neurons assessed as reduction in phosphorylated S6 level incubated for 4 hrs by Hoechst staining based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Mouse)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTOR (unknown origin) by lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM116089(US8633183, E-238)
Affinity DataIC50: 0.0700nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50: 0.0800nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataKd:  0.0920nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50316254(methyl 4-(6-(4-(3-(4-(2-hydroxyethyl)phenyl)ureido...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303299(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50315080(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303298(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303282(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300067(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM127490(US8791131, 268)
Affinity DataKi:  0.117nM ΔG°:  -56.7kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306640(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306624(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-is...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306639(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataKd:  0.140nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50315071(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM174595(US9102670, 14a)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300072(methyl 4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306638(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Mouse)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50535638(CHEMBL4529771)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300077(ethyl 4-(6-(4-(3-ethylureido)phenyl)-4-morpholino-...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.180nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50315056(1-(4-(4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300070(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306633(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human recombinant mTOR assessed as decrease in phosphorylation of S6K level at Thr389 incubated for 2 hrs in presence of ATP and His6-S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306633(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human full-length Flag-tagged mTOR expressed in HEK293 cells using His6-S6K as substrate measured after 2 hrs in presence of ATP by DEL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50306620(isopropyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-y...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303292(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM116093(US8633183, E-242)
Affinity DataIC50: 0.200nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315095(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50316255(Isopropyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpho...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315097(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303295(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303281(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50303280(4-(3-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300071(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300075(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50089318(CHEMBL3577911)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR (unknown origin) using GFP-4E-BP1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
Displayed 1 to 50 (of 7231 total ) | Next | Last >>
Jump to: