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Report error Found 81 Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 2'
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50561183(CHEMBL4787693)
Affinity DataEC50:  0.0240nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50561185(CHEMBL4749661)
Affinity DataEC50:  0.0270nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50561184(CHEMBL4762592)
Affinity DataEC50:  0.290nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  47nMAssay Description:Inhibition of human SK2 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 59nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50084848(BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...)
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50356161(CHEMBL1909931)
Affinity DataKi:  90nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50289333(21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.1...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583213(CHEMBL5086997)
Affinity DataEC50:  91nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50084852(4N-[10-(1-methyl-4-quinoliniumylamino)decyl]-1-[3-...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583211(CHEMBL5078247)
Affinity DataEC50:  110nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 123nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50084849(Bis-quinolinium cyclophane analogue | Cyclo(N-deca...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50084839(Bis-quinolinium cyclophane analogue | cyclo N-deca...)
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50084851(Bis-quinolinium cyclophane analogue | Cyclo N-deca...)
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50054105(1-{4-[2-[4-(4-amino-1-quinoliniumylmethyl)phenyl]-...)
Affinity DataIC50: 190nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50356159(CHEMBL1909929)
Affinity DataKi:  194nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataKi:  277nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataKi:  284nMAssay Description:Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50054098(CHEMBL6354 | 1-{3-[3-(4-amino-1-quinoliniumylmethy...)
Affinity DataIC50: 290nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataKi:  306nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50084846(1-[7-(4-amino-1-quinoliniumylmethyl)-9H-2-fluoreny...)
Affinity DataIC50: 310nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50054103(CHEMBL269729 | CHEMBL370040 | 1-{4-[4-(4-amino-1-q...)
Affinity DataIC50: 380nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50356162(CHEMBL1909932)
Affinity DataKi:  397nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50054095(CHEMBL429017 | CHEMBL362961 | 1-{4-[4-(4-amino-1-q...)
Affinity DataIC50: 410nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50054096(1.1'-[methylenebis(benzene-1,4-diylmethylene)]bis(...)
Affinity DataIC50: 450nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 530nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 543nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50356158(CHEMBL1909928)
Affinity DataKi:  593nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583213(CHEMBL5086997)
Affinity DataEC50:  640nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50048412(4N-[10-(1-benzyl-4-quinoliniumylamino)decyl]-1-ben...)
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50275184(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Affinity DataEC50:  800nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM50356160(CHEMBL1909930)
Affinity DataKi:  878nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583211(CHEMBL5078247)
Affinity DataEC50:  990nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50626104(CHEMBL1182643)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50423643(CEPHARANTHINE)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50356161(CHEMBL1909931)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of cloned rat SK2 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50626105(CHEMBL1185254)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50618500(CHEMBL5421015)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583210(CHEMBL5074700)
Affinity DataEC50:  1.89E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583212(CHEMBL5076878)
Affinity DataEC50:  1.99E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of SK2 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583214(CHEMBL5076032)
Affinity DataEC50:  2.97E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583216(CHEMBL5081906)
Affinity DataEC50:  3.27E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583215(CHEMBL5075016)
Affinity DataEC50:  3.45E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583223(CHEMBL5077913)
Affinity DataEC50:  3.59E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583231(CHEMBL5094656)
Affinity DataEC50:  4.32E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50583220(CHEMBL5079766)
Affinity DataEC50:  4.51E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
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