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Report error Found 1001 Enz. Inhib. hit(s) with Target = 'Synaptic vesicular amine transporter'
TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to VMAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611952(US11718618, Compound 4-119 | (2R,3R,11bR)-9- (cycl...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611939(US11718618, Compound 4-90 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611867(US11718618, Compound 4-23 | 1-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  0.410nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611873(US11718618, Compound 4-28 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.480nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611905(US11718618, Compound 4-56 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.520nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611877(US11718618, Compound 4-32 | (2R,3R,11bR)-9-cyclobu...)
Affinity DataKi:  0.590nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611937(US11718618, Compound 4-88 | (2R,3R,11bR)-9- (cyclo...)
Affinity DataKi:  0.680nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611954(US11718618, Compound 4-121 | (2R,3R,11bR)-9-[(2,2-...)
Affinity DataKi:  0.820nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611906(US11718618, Compound 4-57 | (2R,3R,11bR)-9-{[1- (d...)
Affinity DataKi:  0.930nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Bovine)
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataKi:  1nMAssay Description:Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghostsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611872(US11718618, Compound 4-27 | (2R,3R,11bR)-9-cyclopr...)
Affinity DataKi:  1nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.03nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611856(US11718618, Compound 4-15 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611900(US11718618, Compound 4-55 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter [V41A](Rat)
Hebrew University of Jerusalem

LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 1.30nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611895(US11718618, Compound 4-50 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611953(US11718618, Compound 4-120 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611908(US11718618, Compound 4-59 | 5-({[(2R,3R,11bR)-3-(2...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611876(US11718618, Compound 4-31 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.90nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.90nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.90nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter [G308P](Rat)
Hebrew University of Jerusalem

LigandPNGBDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataIC50: 14.5nM Kd:  2nMpH: 7.5 T: 2°CAssay Description:Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2nMAssay Description:Inhibition of VMAT2 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2nMAssay Description:Inhibition of VMAT2 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter [G308P](Rat)
Hebrew University of Jerusalem

LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 2nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611950(US11718618, Compound 4-117 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611854(US11718618, Compound 4-13 | (2R,3R,11bR)-9-(2,2- d...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611889(US11718618, Compound 4-44 | 2-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611842(US11718618, Compound 4-1 | (2R,3R,11bR)-3-(2,2- di...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.45nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611897((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-(methoxy- d...)
Affinity DataKi:  2.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 2.5nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50048893((2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-2-methyl-1,...)
Affinity DataKi:  2.60nMAssay Description:In vitro inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM516376(US11053242, Compound 1-1)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611855(US11718618, Compound 4-14 | (2R,3R,11bR)-9-(2,2- d...)
Affinity DataKi:  2.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611909(US11718618, Compound 4-60 | (2R,3R,11bR)-9-(benzyl...)
Affinity DataKi:  3.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50: 3.39nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611853(US11718618, Compound 4-12 | (2S,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  3.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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