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Found 42 with Last Name = 'stivers' and Initial = 'j'
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26621(4-[dihydroxy(oxo)--stibanyl]-2-nitrobenzoic acid |...)
Affinity DataKi:  19nM ΔG°:  -43.6kJ/mole IC50:  4nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26622(Compound 13793 | ethyl 4-{4-[dihydroxy(oxo)--stiba...)
Affinity DataKi:  36nM ΔG°:  -42.1kJ/mole IC50:  17nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataKi:  72nMAssay Description:Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataKi:  369nMAssay Description:Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUracil-DNA glycosylase(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM36456(6-[3-(Aminooxypropylamino)methyl]uracil, dihydroch...)
Affinity DataKi:  7.00E+5nMpH: 8.0Assay Description:Inhibition of human uracil DNA glycosylase using high-throughput fluorescent molecular beacon DNA substrate.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUracil-DNA glycosylase(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM36457(3-[(3-Aminopropoxyimino)methyl]uracil, hydrochlori...)
Affinity DataKi:  7.50E+5nMpH: 8.0Assay Description:Inhibition of human uracil DNA glycosylase using high-throughput fluorescent molecular beacon DNA substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50:  100nMAssay Description:Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26618(Compound 15596 | N-{4-[dihydroxy(oxo)--stibanyl]ph...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  770nMAssay Description:Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUracil-DNA glycosylase(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM36453(6-[3-[(3-Carboxy-benzylidene)aminooxypropylamino]-...)
Affinity DataIC50:  1.30E+3nMpH: 8.0Assay Description:Inhibition of human uracil DNA glycosylase using high-throughput fluorescent molecular beacon DNA substrate.More data for this Ligand-Target Pair
TargetPhosphatidylglycerophosphatase and protein-tyrosine phosphatase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50:  3.15E+3nMAssay Description:Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50:  5.67E+3nMAssay Description:Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  7.93E+3nMAssay Description:Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50:  8.87E+3nMAssay Description:Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant His-tagged VHR using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylglycerophosphatase and protein-tyrosine phosphatase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUracil-DNA glycosylase(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM36452(6-[[(3-Carboxy-benzylidene)-aminooxy]ethoxyimino]m...)
Affinity DataIC50:  4.00E+4nMpH: 8.0Assay Description:Inhibition of human uracil DNA glycosylase using high-throughput fluorescent molecular beacon DNA substrate.More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant His-tagged VHR using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUracil-DNA glycosylase(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM36454(6-[[3-(3-Carboxybenzyl)aminopropylimino]methyl]ura...)
Affinity DataIC50:  1.00E+5nMpH: 8.0Assay Description:Inhibition of human uracil DNA glycosylase using high-throughput fluorescent molecular beacon DNA substrate.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50388723(CHEMBL2057662)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUracil-DNA glycosylase(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM36455(6-[4-[(3-Carboxybenzylamino)butylamino]methyl]urac...)
Affinity DataIC50:  3.15E+5nMpH: 8.0Assay Description:Inhibition of human uracil DNA glycosylase using high-throughput fluorescent molecular beacon DNA substrate.More data for this Ligand-Target Pair
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26619(2,2,2,5-tetrahydroxy-1,3,2-dioxastibinane-4,6-dica...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26617(4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxy...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26616(2-aminobenzene-1,3,5-trisulfonamide | Compound 258...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26614(2-[(4-hydroxy-3-methylphenyl)[(1Z)-3-methyl-4-oxoc...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26612(2,3-dinitro-9H-fluoren-9-one | Compound 133896)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26611((hydrazinecarbonyl)-N-(pyrimidin-2-yl)methanesulfo...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26620(4-amino-5-{[(4-methylbenzene)sulfonyl]oxy}naphthal...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26615(8-(8-carboxynaphthalen-1-yl)naphthalene-1-carboxyl...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed