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Found 239 with Last Name = 'gowan' and Initial = 'r'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382322(CHEMBL2024689)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50222709(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491689(CHEMBL2387425)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491647(CHEMBL2387019)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491682(CHEMBL2387423)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491698(CHEMBL2387426)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491681(CHEMBL2387427)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50222709(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50060140(CHEMBL115943 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-cy...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491680(CHEMBL2387429)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491693(CHEMBL2387428)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50060144(CHEMBL325073 | [(S)-1-{(4-Benzyloxy-benzyl)-[((R)-...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382320(CHEMBL2024687)
Affinity DataIC50:  3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491679(CHEMBL2387430 | US11419874, Example 3)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491694(CHEMBL2385104)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50476830(CHEMBL442235)
Affinity DataIC50:  4nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50060141(CHEMBL431440 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-me...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382319(CHEMBL2024686)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50055595(CHEMBL304691 | [(R)-1-((R)-2-(4-Benzyloxy-phenyl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382318(CHEMBL2024685)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491651(CHEMBL2387143)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50476834(CHEMBL234887)
Affinity DataIC50:  5nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382325(CHEMBL2024693)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50060149(CHEMBL112512 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50060145(CHEMBL115669 | [(S)-1-{(4-Benzyloxy-benzyl)-[((S)-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50060139(CHEMBL326352 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-p...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382323(CHEMBL2024690)
Affinity DataIC50:  6nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50055604(CHEMBL441189 | [(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat brain farnesyltransferase in 50 mM HEPES bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491699(CHEMBL2387422)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50060146(CHEMBL407445 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-p...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491690(CHEMBL2387441)
Affinity DataIC50:  7nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50060138(CHEMBL324827 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50055633(CHEMBL384416 | [(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(...)
Affinity DataIC50:  8.5nMAssay Description:Inhibitory concentration against rat brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50408250(CHEMBL2115092)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against rat brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50055604(CHEMBL441189 | [(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(...)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat brain farnesyltransferase in 5 mM potassium phosphate and 50 mM HEPES bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491697(CHEMBL2387424)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50059876(CHEMBL217423 | [(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382317(CHEMBL2024684)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50055604(CHEMBL441189 | [(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(...)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat brain farnesyltransferase in 30 mM potassium phosphate bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50491692(CHEMBL2387436)
Affinity DataIC50:  14nMAssay Description:Inhibition of PDE2 catalytic domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50055631(CHEMBL429183 | [(R)-1-((R)-2-(4-Benzyloxy-phenyl)-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against rat brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369314(CHEMBL1790438)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against rat brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50132260(2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmetho...)
Affinity DataIC50:  16nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50060150(CHEMBL114281 | [(S)-1-{(4-Benzyloxy-benzyl)-[((R)-...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50060142(CHEMBL326127 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-p...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of rat farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50476829(CHEMBL396548)
Affinity DataIC50:  17nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50476834(CHEMBL234887)
Affinity DataIC50:  18nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50055636(4-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethyl...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration against rat brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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