Affinity DataKi: 3.40nMAssay Description:Binding affinity against Thymidylate synthase was measured in vitroMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity against Thymidylate synthase was measured in vitroMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Concentration required for in vitro inhibition of thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 75nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Inhibition of PTP1B I219A mutantMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 710nMAssay Description:Inhibition of TCPTP I220A mutantMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of PTP1B I219A mutantMore data for this Ligand-Target Pair
Affinity DataKi: 2.25E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
Affinity DataKi: >2.66E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Inhibition of wild type PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Inhibition of TCPTPMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Inhibition of PTP1B I219A mutantMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 2.70E+4nMAssay Description:Inhibition of PTP1B V49A mutantMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: 3.40E+4nMAssay Description:Inhibition of wild type PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Amherst College
Curated by ChEMBL
Amherst College
Curated by ChEMBL
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of wild type PTP1BMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of protein tyrosine kinasesMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of protein tyrosine kinasesMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Concentration of the compound required to inhibit 50% activity of Thymidylate synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of thymidylate synthase from L1210 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of partially purified thymidylate synthase (TS)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration of the compound required to inhibit 50% activity of Thymidylate synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration of the compound required to inhibit 50% activity of Thymidylate synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory activity against thymidylate synthase (TS) from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration required for in vitro inhibition of thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:In vitro inhibitory activity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Concentration of the compound required to inhibit 50% activity of Thymidylate synthase was determinedMore data for this Ligand-Target Pair