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Found 481 with Last Name = 'butler' and Initial = 'k'
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  0.800nM IC50:  4nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)

Curated by ChEMBL
LigandPNGBDBM50591671(CHEMBL5191603)
Affinity DataKi:  0.900nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  1.30nM IC50:  5nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)

Curated by ChEMBL
LigandPNGBDBM50591673(CHEMBL5198400)
Affinity DataKi:  2.40nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)

Curated by ChEMBL
LigandPNGBDBM50591672(CHEMBL5184798)
Affinity DataKi:  2.60nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)

Curated by ChEMBL
LigandPNGBDBM50591674(CHEMBL5173140)
Affinity DataKi:  2.80nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
University of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  3nM IC50:  9nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082611(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  5.70nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082575(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090249(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  6nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082578(6-Chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline...)
Affinity DataKi:  6.60nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)

Curated by ChEMBL
LigandPNGBDBM50591676(CHEMBL5202369)
Affinity DataKi:  7.70nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  11nM IC50:  30nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082589(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  11nMAssay Description:The compound was evaluated for the inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082579(6-Chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082583(Acetic acid 2-{1-[5-guanidino-2-(3-methyl-1,2,3,4-...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  17nM IC50:  42nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073283(4-[(S)-1-Hydroxymethyl-2-(4-methoxy-phenyl)-ethyla...)
Affinity DataKi:  19nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082589(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073297(4-[(S)-1-(4-Hydroxy-piperidin-1-ylmethyl)-2-phenyl...)
Affinity DataKi:  19nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073283(4-[(S)-1-Hydroxymethyl-2-(4-methoxy-phenyl)-ethyla...)
Affinity DataKi:  19nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073298(4-((S)-1-Benzyl-2-morpholin-4-yl-ethylamino)-pyrid...)
Affinity DataKi:  22nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073298(4-((S)-1-Benzyl-2-morpholin-4-yl-ethylamino)-pyrid...)
Affinity DataKi:  22nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  23nM IC50:  83nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082598(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082577(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073294(4-((S)-1-Benzyl-2-dimethylamino-ethylamino)-pyridi...)
Affinity DataKi:  24nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077058(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  26nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082612(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090244(3,3-Dimethyl-6-[3-oxo-3-(4-pyridin-4-ylmethyl-pipe...)
Affinity DataKi:  27nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50075870(4-[(S)-1-(2-Hydroxy-ethoxymethyl)-2-phenyl-ethylam...)
Affinity DataKi:  28nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)

Curated by ChEMBL
LigandPNGBDBM50591678(CHEMBL5174448)
Affinity DataKi:  31nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082580(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  32nMAssay Description:The compound was evaluated for the inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090250(3-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  34nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090247(6-[3-(4-Acetyl-piperazin-1-yl)-3-oxo-propyl]-3,3-d...)
Affinity DataKi:  34nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082608(CHEMBL139718 | Succinic acid mono-(2-{1-[5-guanidi...)
Affinity DataKi:  34nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090243(6-(2-Hydroxy-ethyl)-3,3-dimethyl-1,2,3,4-tetrahydr...)
Affinity DataKi:  39nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073295(4-((S)-1-Hydroxymethyl-2-phenyl-ethylamino)-pyridi...)
Affinity DataKi:  39nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073295(4-((S)-1-Hydroxymethyl-2-phenyl-ethylamino)-pyridi...)
Affinity DataKi:  39nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50075873(4-[(S)-1-Hydroxymethyl-2-(4-methoxy-phenyl)-ethyla...)
Affinity DataKi:  40nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082581(CHEMBL143203 | N-(2-{1-[2-(3,3-Dimethyl-1,2,3,4-te...)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082573(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  44nMAssay Description:The compound was evaluated for the inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082591(CHEMBL139606 | N-(2-{1-[5-Guanidino-2-(3-methyl-1,...)
Affinity DataKi:  45nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082603((R)-3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  46nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090246(3,3-Dimethyl-6-(2-ureido-ethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  47nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082580(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  48nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073292(4-[(S)-1-(2-Hydroxy-ethoxymethyl)-2-phenyl-ethylam...)
Affinity DataKi:  49nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50073292(4-[(S)-1-(2-Hydroxy-ethoxymethyl)-2-phenyl-ethylam...)
Affinity DataKi:  49nMAssay Description:In vitro inhibtion of human thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082594(CHEMBL356067 | N-[1-(3,4-Dihydro-1H-isoquinoline-2...)
Affinity DataKi:  49nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082573(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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