Found 449 with Last Name = 'co' and Initial = 'ew' Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 0.126nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 251nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 316nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus with [3H]8-OH-DPATMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against muscarinic M1 receptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against alpha-1 adrenoceptorMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against alpha-2 adrenoceptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against muscarinic M2 receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against muscarinic M3 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 1.26E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus with [3H]8-OH-DPATMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 1.26E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 5.01E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 6.31E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine D3 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine D2 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Mus musculus (Mouse))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+4nMAssay Description:Tested for 5-hydroxytryptamine receptor uptakeMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine receptor D1More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Glaxo Research And Development
Curated by ChEMBL
Glaxo Research And Development
Curated by ChEMBL
Affinity DataKi: 2.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1 after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 1.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 1.80nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha after 2 hrs by luciferase-luciferin coupled chemiluminescence assayMore data for this Ligand-Target Pair
