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Found 577 with Last Name = 'de paulis' and Initial = 't'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007522(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50368060(CHEMBL1907695)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007508((R) N-(1-Benzyl-pyrrolidin-2-ylmethyl)-5-bromo-2,3...)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50368067(CHEMBL1907702)
Affinity DataKi:  0.0330nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007517((S)-3-bromo-N-((1-ethylpyrrolidin-2-yl)methyl)-2-h...)
Affinity DataKi:  0.0640nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007517((S)-3-bromo-N-((1-ethylpyrrolidin-2-yl)methyl)-2-h...)
Affinity DataKi:  0.0640nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50368065(CHEMBL1907692)
Affinity DataKi:  0.0870nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007518((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007509(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,6...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.160nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007510((R) 3-Bromo-N-[1-(4-fluoro-benzyl)-pyrrolidin-2-yl...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50241107(1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazo...)
Affinity DataKi:  0.280nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50241107(1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazo...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007524((R) 3-Bromo-N-[1-(4-fluoro-benzyl)-pyrrolidin-2-yl...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50241107(1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazo...)
Affinity DataKi:  0.530nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  0.540nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  0.540nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50010724(CHEMBL305916 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50453039(CHEMBL2096749)
Affinity DataKi:  0.800nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028602(1-(2-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  0.900nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028601(1-(8-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  1nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028601(1-(8-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  1nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50005118((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50005118((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  1.40nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  2nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028601(1-(8-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  2nMAssay Description:Affinity was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
In DepthDetails PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  2.20nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  2.5nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  2.5nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Astra Research Centre

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028602(1-(2-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Affinity was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Affinity of the compound was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C recept...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2C serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036437(4-Dibenzo[b,f]oxepin-10-yl-1-methyl-piperidine; hy...)
Affinity DataKi:  3nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028976(4-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-me...)
Affinity DataKi:  3nMAssay Description:Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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