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Found 126 with Last Name = 'higgins' and Initial = 'ga'
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM79215(CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...)
Affinity DataKi:  0.126nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178575(2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-(4-hydroxy...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178558(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178565(CHEMBL206488 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243660(2-Furan-2-yl-7-[2-(7-nitro-1,2,4,5-tetrahydro-benz...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178574(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178561(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243661(7-[2-(7-Bromo-1,2,4,5-tetrahydro-benzo[d]azepin-3-...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178572(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM79215(CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178586(2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178581(2'-methyl-5-(4-methyl-piperazin-1-yl)-biphenyl-2-c...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243027(2-Furan-2-yl-7-{2-[8-(2-methoxy-ethoxy)-3,4-dihydr...)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242875(7-[2-(3-Bromo-7,8-dihydro-5H-[1,6]naphthyridin-6-y...)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178562(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178557(CHEMBL205829 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243025(7-[2-(6,7-Dimethoxy-3-methyl-3,4-dihydro-1H-isoqui...)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243696(2-Furan-2-yl-7-[2-(7-methoxy-1,2,4,5-tetrahydro-be...)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242874(7-[2-(3-Cyclopropyl-7,8-dihydro-5H-[1,6]naphthyrid...)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242873(2-Furan-2-yl-7-[2-(3-methyl-7,8-dihydro-5H-[1,6]na...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243697(2-Furan-2-yl-7-{2-[7-(2-methoxy-ethoxy)-1,2,4,5-te...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243659(2-Furan-2-yl-7-[2-(1,2,4,5-tetrahydro-benzo[d]azep...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178582(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243026(7-[2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoqui...)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243028(2-Furan-2-yl-7-[2-(6-methoxy-3,4-dihydro-1H-isoqui...)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242876(2-Furan-2-yl-7-{2-[3-(2-methoxy-ethoxy)-7,8-dihydr...)
Affinity DataKi:  3.10nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(GUINEA PIG)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50469882(CHEMBL73446)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM79215(CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(GUINEA PIG)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50469879(CHEMBL72088)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(GUINEA PIG)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM79215(CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243029(2-Furan-2-yl-7-[2-(7-methoxy-3,4-dihydro-1H-isoqui...)
Affinity DataKi:  3.20nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243695(7-[2-(7-Chloro-1,2,4,5-tetrahydro-benzo[d]azepin-3...)
Affinity DataKi:  3.30nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178583(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178553(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178584(CHEMBL203605 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178580(CHEMBL265986 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178555(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242937(7-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethyl]-2-fu...)
Affinity DataKi:  4.10nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178585(CHEMBL206294 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243698(7-[2-(7,8-Dihydro-5H-[1,6]naphthyridin-6-yl)-ethyl...)
Affinity DataKi:  4.80nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(GUINEA PIG)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50469875(CHEMBL72981)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(GUINEA PIG)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50469881(CHEMBL311150)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242940(2-Furan-2-yl-7-[2-(2-trifluoromethyl-7,8-dihydro-5...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243658(2-Furan-2-yl-7-{2-[7-(2-methoxy-ethoxy)-3,4-dihydr...)
Affinity DataKi:  5.10nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242936(2-Furan-2-yl-7-[2-(5-methoxy-1,3-dihydro-isoindol-...)
Affinity DataKi:  5.40nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50243657(2-Furan-2-yl-7-[2-(4-methoxy-1,3-dihydro-isoindol-...)
Affinity DataKi:  6nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50242939(7-[2-(7,8-Dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-...)
Affinity DataKi:  6.20nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50178573(CHEMBL381081 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50469876(CHEMBL306384)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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