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Found 164 with Last Name = 'ishibashi' and Initial = 'k'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176892(6-iodo-4'-dimethyaminoflavone | CHEMBL375934)
Affinity DataKi:  13.2nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176892(6-iodo-4'-dimethyaminoflavone | CHEMBL375934)
Affinity DataKi:  15.6nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176896(6-iodo-4'-methylaminoflavone | CHEMBL224643)
Affinity DataKi:  22.6nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176894(6-iodo-4'-methoxyflavone | CHEMBL224064)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176896(6-iodo-4'-methylaminoflavone | CHEMBL224643)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176894(6-iodo-4'-methoxyflavone | CHEMBL224064)
Affinity DataKi:  38.3nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176895(6-iodo-4'-hydroxyflavone | CHEMBL388844)
Affinity DataKi:  72.5nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50176895(6-iodo-4'-hydroxyflavone | CHEMBL388844)
Affinity DataKi:  77.2nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50079267(Congo Red | Direct red 28 | Kongorot | Sodium diph...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Nagasaki University

Curated by ChEMBL
LigandPNGBDBM50079267(Congo Red | Direct red 28 | Kongorot | Sodium diph...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089825(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-nitro-phth...)
Affinity DataIC50:  0.300nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089837(4-(3-Chloro-4-methoxy-benzylamino)-1-thiomorpholin...)
Affinity DataIC50:  0.320nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089826(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-phth...)
Affinity DataIC50:  0.5nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089807(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-oxo-piperi...)
Affinity DataIC50:  0.530nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089833(4-(3-Chloro-4-methoxy-benzylamino)-1-piperidin-1-y...)
Affinity DataIC50:  0.550nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089814(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of phosphodiesterase 5 (PDE5) from porcine platelets, range 0.442-0.710More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089821(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-4-...)
Affinity DataIC50:  0.700nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089827(4-(3-Chloro-4-methoxy-benzylamino)-1-[4-(2-hydroxy...)
Affinity DataIC50:  0.700nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50369544(CHEMBL545012)
Affinity DataIC50:  0.700nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50:  0.720nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089815(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-trifluorom...)
Affinity DataIC50:  0.730nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089841(4-(3-Chloro-4-methoxy-benzylamino)-1-(1,1-dioxo-1l...)
Affinity DataIC50:  0.790nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089832(1-[6,7-Dichloro-4-(3-chloro-4-methoxy-benzylamino)...)
Affinity DataIC50:  0.860nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089820(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxymet...)
Affinity DataIC50:  0.930nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089830(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-methyl-pip...)
Affinity DataIC50:  0.950nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089816(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-methoxy-pi...)
Affinity DataIC50:  1.10nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089809(4-(3-Chloro-4-methoxy-benzylamino)-1-piperazin-1-y...)
Affinity DataIC50:  1.20nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089838(4-(3-Chloro-4-methoxy-benzylamino)-1-(3-hydroxy-pi...)
Affinity DataIC50:  1.20nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089842(4-(3-Chloro-4-methoxy-benzylamino)-1-imidazol-1-yl...)
Affinity DataIC50:  1.5nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089818(4-(3-Chloro-4-methoxy-benzylamino)-1-[4-(2-hydroxy...)
Affinity DataIC50:  1.70nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217526(CHEMBL366972)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against Neurokinin 1 (NK1) receptor from guinea pig lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089812(4-(3-Chloro-4-methoxy-benzylamino)-1-(3,6-dihydro-...)
Affinity DataIC50:  1.90nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089836(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)
Affinity DataIC50:  2nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  2.20nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089817(4-(3-Chloro-4-methoxy-benzylamino)-1-(3-hydroxy-pr...)
Affinity DataIC50:  2.60nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090485(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Affinity DataIC50:  2.70nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089823(4-(3-Chloro-4-methoxy-benzylamino)-1-[(pyridin-2-y...)
Affinity DataIC50:  2.70nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50066450(1-Chloro-4-(3-chloro-4-methoxy-benzylamino)-phthal...)
Affinity DataIC50:  3nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50057477(4-(3-{3-[(4-Isobutyl-benzyl)-(4-isobutyl-phenyl)-a...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against human Steroid 5-alpha-reductase type 1 in COS-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217519(CHEMBL354709)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50:  3.10nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089839(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-phth...)
Affinity DataIC50:  3.10nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217520(CHEMBL354645)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50066454(CHEMBL25616 | Sodium; 1-{4-[(benzo[1,3]dioxol-5-yl...)
Affinity DataIC50:  3.70nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50089808(1-[6-Chloro-4-(3-chloro-4-methoxy-benzylamino)-pht...)
Affinity DataIC50:  4.40nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217517(CHEMBL353158)
Affinity DataIC50:  4.70nMAssay Description:Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217511(CHEMBL172342)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against Neurokinin 1 (NK1) receptor from guinea pig lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217506(CHEMBL170936)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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