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Found 30 with Last Name = 'mcalpine' and Initial = 'sr'
TargetHistone deacetylase 1(Homo sapiens (Human))
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50114871(CHEMBL3609826)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HSF1 (unknown origin) assessed as reduction in HSF1--mediated HSP transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550647(CHEMBL4745048)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550648(CHEMBL4740117)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550645(CHEMBL4777096)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550646(CHEMBL4751004)
Affinity DataIC50:  3.57E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550649(CHEMBL4740901)
Affinity DataIC50:  3.72E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550644(CHEMBL4758278)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550649(CHEMBL4740901)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock-related 70 kDa protein 2(Homo sapiens)
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50518213(CHEMBL4473449)
Affinity DataIC50:  6.43E+3nMAssay Description:Inhibition of (2S,8S,11S,14S)-2-(4-aminobutyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-4,7,10,13,16,32-hexaoxo-36-((3aS,4S,6aR)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50493051(Psammaplysin F)
Affinity DataIC50:  2.26E+4nMAssay Description:Antibacterial activity against Enterococcus faecalis NCTC 775 after 20 to 24 hrs by two-fold broth microdilution methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550650(CHEMBL4788842)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50493050(Psammaplysin H)
Affinity DataIC50:  4.02E+4nMAssay Description:Antibacterial activity against Enterococcus faecalis NCTC 775 after 20 to 24 hrs by two-fold broth microdilution methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HSF1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550651(CHEMBL4760133)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of C-terminal HSP90beta (527 to 724 residues) (unknown origin) interaction with CYP40 measured after 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock-related 70 kDa protein 2(Homo sapiens)
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50518215(CHEMBL4449629)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of (2S,8S,11S,14S)-2-(4-aminobutyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-4,7,10,13,16,32-hexaoxo-36-((3aS,4S,6aR)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock-related 70 kDa protein 2(Homo sapiens)
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50518214(CHEMBL4448551)
Affinity DataIC50:  8.73E+4nMAssay Description:Inhibition of (2S,8S,11S,14S)-2-(4-aminobutyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-4,7,10,13,16,32-hexaoxo-36-((3aS,4S,6aR)...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock-related 70 kDa protein 2(Homo sapiens)
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50518216(CHEMBL4449072)
Affinity DataIC50:  2.48E+5nMAssay Description:Inhibition of (2S,8S,11S,14S)-2-(4-aminobutyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-4,7,10,13,16,32-hexaoxo-36-((3aS,4S,6aR)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550649(CHEMBL4740901)
Affinity DataKd:  4.50E+4nMAssay Description:Binding affinity to HSP90 C-terminal domain (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataKd:  5.00E+5nMAssay Description:Binding affinity to HSP90 C-terminal domain (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50442881(SILYBIN A)
Affinity DataKd:  5.00E+5nMAssay Description:Binding affinity to HSP90 C-terminal domain (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50358580(CHEMBL1923743)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to Hsp90 after 1 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50358579(CHEMBL192264)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to human Hsp90 closed state by fluorescence polarization anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071465(Ascomycin derivative | CHEMBL428499)
Affinity DataEC50:  22nMAssay Description:Binding affinity of the compound for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071466(Ascomycin derivative | CHEMBL386482)
Affinity DataEC50:  7.40nMAssay Description:Binding affinity of the compound for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068939((E)-(9S,12S,13R,14S,17R,21S,23S,24R,25S,27S)-17-Et...)
Affinity DataEC50:  1.60nMAssay Description:Binding affinity of the compound for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071463(Ascomycin derivative | C32-O-cinnamyl ether analog...)
Affinity DataEC50:  30nMAssay Description:Binding affinity of the compound for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071450(Ascomycin derivative | CHEMBL385568)
Affinity DataEC50:  12nMAssay Description:Binding affinity of the compound for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM50550649(CHEMBL4740901)
Affinity DataKd:  1.98E+4nMAssay Description:Binding affinity to recombinant His6-tagged HSP90 C-domain (unknown origin) (553 to 732 residues) expressed in Escherichia coli BL21 (DE3) (DNAY) cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of New South Wales

Curated by ChEMBL
LigandPNGBDBM20732((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to Hsp90 N-domainMore data for this Ligand-Target Pair