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Found 46 with Last Name = 'melloni' and Initial = 'p'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Cns Line

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  1nMAssay Description:Evaluated for the affinity against Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Cns Line

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataIC50:  10nMAssay Description:Evaluated for the affinity against Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408438(CHEMBL2068911)
Affinity DataIC50:  30nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408439(CHEMBL2068890)
Affinity DataIC50:  60nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM66977(3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...)
Affinity DataIC50:  80nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataIC50:  100nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066032(CHEMBL323301 | [(1R,4bR,7S,8aR)-7-Hydroxy-1,4b,8,8...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066031((E)-(S)-4-((2S,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl...)
Affinity DataIC50:  120nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066029(4-[(S)-1-((2S,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl-...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408276(CHEMBL2068996)
Affinity DataIC50:  160nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066036(4-[(R)-1-((2R,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl-...)
Affinity DataIC50:  200nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131828((E,Z)10,13-Dimethyl-tetradecahydro-cyclopenta[a]ph...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161094(US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzyl...)
Affinity DataIC50:  200nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408439(CHEMBL2068890)
Affinity DataIC50:  250nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066034((E)-(R)-4-((2R,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408921(CHEMBL2068972)
Affinity DataIC50:  320nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408437(CHEMBL2068917)
Affinity DataIC50:  350nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM66977(3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM46355(DIGOXIN | MLS000069819 | SMR000059217 | US10668094...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM46355(DIGOXIN | MLS000069819 | SMR000059217 | US10668094...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM66977(3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408917(CHEMBL2068902)
Affinity DataIC50:  1.25E+3nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408916(CHEMBL2068975)
Affinity DataIC50:  1.58E+3nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408275(CHEMBL2068885)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408282(CHEMBL2069057)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408281(CHEMBL2068935 | CHEMBL2068940)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408279(CHEMBL2069128)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408280(CHEMBL2068992)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408440(CHEMBL2068987)
Affinity DataIC50:  5.89E+3nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131829((E)4,10,13-Trimethyl-tetradecahydro-cyclopenta[a]p...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408920(CHEMBL2069058)
Affinity DataIC50:  6.30E+3nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408281(CHEMBL2068935 | CHEMBL2068940)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408278(CHEMBL2068942)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408277(CHEMBL2068936)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131821((E,Z)10,13-Dimethyl-tetradecahydro-cyclopenta[a]ph...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity against Na+/K+ ATPase measured by 32P-ATP hydrolysis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131832((E)2,10,13-Trimethyl-tetradecahydro-cyclopenta[a]p...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408915(CHEMBL2068981)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408914(CHEMBL2068977)
Affinity DataIC50:  4.00E+4nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131823((E,Z)6,17-Dihydroxy-10,13-dimethyl-hexadecahydro-c...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against Na+/K+ ATPase was determined in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408918(CHEMBL2068898 | CHEMBL2068976)
Affinity DataIC50:  1.00E+5nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1(Canis familiaris)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408918(CHEMBL2068898 | CHEMBL2068976)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161089(US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N-met...)
Affinity DataIC50:  1.10E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161090(US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-d...)
Affinity DataIC50:  2.31E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161093(US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-d...)
Affinity DataIC50: >3.00E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161091(US9051240, 2-[2-(3-Butoxy-2,6-difluorophenyl)-ethy...)
Affinity DataIC50: >3.00E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161092(US9051240, 2-[2-(3-Butoxy-4-methoxyphenyl)-ethylam...)
Affinity DataIC50: >3.00E+5nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In DepthDetails US Patent