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Found 304 with Last Name = 'millham' and Initial = 'ml'
LigandPNGBDBM50344013(CHEMBL1780094 | trans-(3R,5S)-N-((6-aminopyridin-2...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081070(CHEMBL3421892)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity to human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081073(CHEMBL3421889)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081070(CHEMBL3421892)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081069(CHEMBL3421871)
Affinity DataIC50:  0.600nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081072(CHEMBL3421890)
Affinity DataIC50:  0.600nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081072(CHEMBL3421890)
Affinity DataIC50:  0.670nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081101(CHEMBL3421879)
Affinity DataIC50:  0.790nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344014(CHEMBL1779987 | trans-(3R,5S)-1-((5-methyl-2-pheny...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390333(CHEMBL2070733)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344015(CHEMBL1780096 | trans-(3S,5S)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  0.955nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081068(CHEMBL3421872)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390334(CHEMBL2070735)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081063(CHEMBL3421875)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276129((2S,4bR,8aR)-4b-Ethyl-7-phenyl-4b,5,6,7,8,8a,9,10-...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081062(CHEMBL3421876)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081079(CHEMBL3421886)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081062(CHEMBL3421876)
Affinity DataIC50:  1.5nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081101(CHEMBL3421879)
Affinity DataIC50:  1.5nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276434((2R,4aR,10aR)-4a-Propyl-2-prop-1-ynyl-1,2,3,4,4a,9...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276127((2R,3S,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylm...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390332(CHEMBL2070732)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081071(CHEMBL3421891)
Affinity DataIC50:  1.70nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344017(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1.80nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
LigandPNGBDBM50344018(CHEMBL1779984 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344016(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390334(CHEMBL2070735)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081079(CHEMBL3421886)
Affinity DataIC50:  1.90nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344019(CHEMBL1780085 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  1.96nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081095(CHEMBL3421885)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276438((2R,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylmeth...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081075(CHEMBL3421887)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276126((2R,3S,4aR,10aR)-4a-Ethyl-2-phenyl-1,2,3,4,4a,9,10...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344020(CHEMBL1780116 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  2.91nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276437((2R,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-7-(pyridin-4-...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344021(CHEMBL1779988 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276472((2R,3S,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylm...)
Affinity DataIC50:  3.30nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081069(CHEMBL3421871)
Affinity DataIC50:  3.5nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  3.5nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276171((2R,4aS,10aR)-4a-Propenyl-2-prop-1-ynyl-1,2,3,4,4a...)
Affinity DataIC50:  3.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390373(CHEMBL2070914)
Affinity DataIC50:  3.63nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276128((2R,3R,4aR,10aR)-4a-Ethyl-2-phenyl-1,2,3,4,4a,9,10...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50276128((2R,3R,4aR,10aR)-4a-Ethyl-2-phenyl-1,2,3,4,4a,9,10...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344022(CHEMBL1780100 | trans-(3S,5S)-5-(3-methyl-1,2,4-ox...)
Affinity DataIC50:  3.86nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344023(CHEMBL1780089 | trans-(3R,5R)-5-(3-methyl-1,2,4-ox...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50081073(CHEMBL3421889)
Affinity DataIC50:  4nMAssay Description:Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390335(CHEMBL2070736)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344024(CHEMBL1780097 | trans-(3S,5S)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344025(CHEMBL1780105 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  4.36nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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