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Found 160 with Last Name = 'paulke' and Initial = 'a'
TargetHistamine H3 receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394646(CHEMBL2164608)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394647(CHEMBL2164610)
Affinity DataKi:  23.4nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394645(CHEMBL2164609)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM27213(4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imi...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394644(CHEMBL2164612)
Affinity DataKi:  135nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394648(CHEMBL2164611)
Affinity DataKi:  219nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394649(CHEMBL2164613)
Affinity DataKi:  678nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394644(CHEMBL2164612)
Affinity DataKi:  902nMAssay Description:Displacement of [3H]PGE2 from human EP4R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394650(CHEMBL2164614)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  1.49E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394651(CHEMBL2164607)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]PGE2 from human EP3R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  1.66E+3nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50159774((E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-pro...)
Affinity DataKi:  1.73E+3nMAssay Description:Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  1.97E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50193918(3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-...)
Affinity DataKi:  2.42E+3nMAssay Description:Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50193918(3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-...)
Affinity DataKi:  2.44E+3nMAssay Description:Displacement of [3H]PGE2 from human EP1R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394644(CHEMBL2164612)
Affinity DataKi:  2.94E+3nMAssay Description:Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394646(CHEMBL2164608)
Affinity DataKi:  3.18E+3nMAssay Description:Displacement of [3H]PGE2 from human EP4R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394646(CHEMBL2164608)
Affinity DataKi:  4.26E+3nMAssay Description:Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50193918(3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-...)
Affinity DataKi:  4.30E+3nMAssay Description:Displacement of [3H]PGE2 from human EP4R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  5.21E+3nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50159774((E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-pro...)
Affinity DataKi:  6.31E+3nMAssay Description:Displacement of [3H]PGE2 from human EP4R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  7.48E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394645(CHEMBL2164609)
Affinity DataKi:  9.45E+3nMAssay Description:Displacement of [3H]PGE2 from human EP4R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394645(CHEMBL2164609)
Affinity DataKi:  1.08E+4nMAssay Description:Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50426502(Bodilisant | CHEMBL2323582)
Affinity DataKi:  1.25E+4nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394646(CHEMBL2164608)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]PGE2 from human EP1R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394645(CHEMBL2164609)
Affinity DataKi:  2.03E+4nMAssay Description:Displacement of [3H]PGE2 from human EP1R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394644(CHEMBL2164612)
Affinity DataKi:  6.86E+4nMAssay Description:Displacement of [3H]PGE2 from human EP1R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50159774((E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-pro...)
Affinity DataKi:  1.51E+5nMAssay Description:Displacement of [3H]PGE2 from human EP1R expressed in chem1 cells after 2hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataIC50:  1nMAssay Description:Inhibition of sEH in human HepG2 cells using 14(15)-EET-d11 as substrate assessed as reduction in conversion of 14(15)-EET-d11 to 14(15)-DHET-d11 pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant v-Abl tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241151(CHEMBL4087681)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241160(CHEMBL4095371)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241158(CHEMBL4064739)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241150(CHEMBL4094881)
Affinity DataIC50:  137nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241109(CHEMBL4076701)
Affinity DataIC50:  157nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241136(CHEMBL4088582)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241146(CHEMBL4092436)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241147(CHEMBL4084686)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10894(4-(4-tert-Butylphenylcarboxamidomethyl)benzenesulf...)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241176(CHEMBL4074393)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241144(CHEMBL1300445)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant v-Abl tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241104(CHEMBL4091019)
Affinity DataIC50:  510nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241145(CHEMBL4100178)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant v-Abl tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241168(CHEMBL4061980)
Affinity DataIC50:  650nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241086(CHEMBL4071919)
Affinity DataIC50:  660nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241139(CHEMBL4076274)
Affinity DataIC50:  680nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241141(CHEMBL4083383)
Affinity DataIC50:  910nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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