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Found 1581 with Last Name = 'roth' and Initial = 'd'
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50243396(CHEMBL1231520)
Affinity DataKi:  6nMAssay Description:Inhibition of human AICARFTMore data for this Ligand-Target Pair
LigandPNGBDBM50073729((R)-3-[(S)-2-(Adamantan-2-yloxycarbonylamino)-3-(1...)
Affinity DataIC50:  0.150nMAssay Description:In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50111776(CHEMBL3605361)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50111774(CHEMBL3605359)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50317179(2-Methyl-9-[9-(2-methyl-beta-carboline-9-yl)nonyl]...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50111775(CHEMBL3605360)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084286(2-(4'-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084286(2-(4'-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50063665(CHEMBL9203 | N-(3-nitrophenyl)-2-[3,4-dihydro-3-[3...)
Affinity DataIC50:  1nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231035(CHEMBL401950 | sodium; (3R,5R)-7-[3-(3-carbamoylme...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50063640(CHEMBL9405 | N-(3-cyanobenzene)-2-[3,4-dihydro-3-[...)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50063630(CHEMBL9188 | N-(3-ethylesterbenzoicacid)-2-[3,4-di...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50449787(CHEMBL2062154 | PD-134308)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449747(CHEMBL2304062)
Affinity DataIC50:  1.70nMAssay Description:In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.More data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231037(CHEMBL253054 | sodium (3R,5R)-7-(3-(azetidin-1-yls...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50063616(CHEMBL8890 | N-(3-tert-butylbenzoicacid)-2-[3,4-di...)
Affinity DataIC50:  1.90nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084291(2-(4'-Bromo-biphenyl-4-sulfonylamino)-4-phenylmeth...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084283((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231039(CHEMBL252657 | sodium; (3R,5R)-7-[2,3-bis-(4-fluor...)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50011204(CHEMBL2368094 | Sodium; 7-[4-(4-fluoro-phenyl)-2-i...)
Affinity DataIC50:  2nMAssay Description:Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50111778(CHEMBL3605363)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50281284(CHEMBL433384 | [[(S)-2-(Adamantan-2-yloxycarbonyla...)
Affinity DataIC50:  2.30nMAssay Description:In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50063666(CHEMBL266557 | N-(3-ethylesterbenzoicacid)-2-[3,4-...)
Affinity DataIC50:  2.40nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231028(CHEMBL429487 | sodium (3R,5R)-7-(2-(4-fluorophenyl...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231019(CHEMBL402622 | sodium (3R,5R)-7-(2-(4-fluorophenyl...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231020(CHEMBL437783 | sodium (3R,5R)-7-(2-(4-fluorophenyl...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084283((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chroma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347385(CHEMBL1801250)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant HDAC1 using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50111780(CHEMBL3605365)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM18372((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM22164((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylca...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Chroma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347385(CHEMBL1801250)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084297(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-(3-phenyl-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084297(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-(3-phenyl-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084304((4'-Bromo-biphenyl-4-sulfonylamino)-acetic acid | ...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50111777(CHEMBL3605362)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of BChE in equine serum using butyrylthiocholine iodide substrate by Ellman assayMore data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231024(CHEMBL401949 | sodium (3R,5R)-7-(2-(4-fluorophenyl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50231026(CHEMBL253258 | sodium; (3R,5R)-7-[2,3-bis-(4-fluor...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051461(CHEMBL264861 | N-(2,6-Diisopropyl-phenyl)-2-(2-dod...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 of liver microsomes isolated from cholesterol-fed rats.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50063636(CHEMBL9406 | N-(3-ethylesterbenzoicacid)-2-[3,4-di...)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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