Compile Data Set for Download or QSAR
maximum 50k data
Found 600 with Last Name = 'tai' and Initial = 'k'
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50116105(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Affinity DataKi:  8.30nMAssay Description:Antagonist activity at human CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420920(CHEMBL2087549 | CHEMBL2087567)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  44nMAssay Description:Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  57nMAssay Description:Inhibition constant for Tyr31-dihydrofolate reductase (DHFR)-NADPH-Compound complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  330nMAssay Description:Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 9.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.1kJ/molepH: 5.5 T: 2°CAssay Description:Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  9.10E+3nMAssay Description:Dissociation constant at(Koff) Tyr-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420920(CHEMBL2087549 | CHEMBL2087567)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human CRF2 receptor expressed in IMR32 cells assessed as inhibition of CRF-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  1.70E+5nMAssay Description:Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 8.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084833(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Affinity DataIC50:  0.450nMAssay Description:Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  0.620nMAssay Description:Binding affinity against Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  0.890nMAssay Description:Binding affinity for Retinoic acid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor beta(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataIC50:  0.940nMAssay Description:Binding affinity for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084832(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084835(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084832(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  2.40nMAssay Description:Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084834(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity for Retinoic Acid Receptor beta (RAR beta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161301(2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzy...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084830(4-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50116105(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CRF1 receptor in human IMR32 cells assessed as inhibition of CRF-induced intracellular cAMP accumulation after 30 mins by immu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161305((3-Aminooxalyl-1-cyclohexylmethyl-2-methyl-2,3-dih...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084832(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  4.5nMAssay Description:Binding affinity for Retinoic Acid Receptor beta (RAR beta)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084831(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  4.60nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161293((3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydr...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161299((3-Aminooxalyl-1-benzyl-2-ethyl-1,6,7,8-tetrahydro...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161301(2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzy...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50398565(CHEMBL2179195)
Affinity DataIC50:  7.10nMAssay Description:Antagonist activity at CRF1 receptor in human IMR32 cells assessed as inhibition of CRF-induced intracellular cAMP accumulation after 30 mins by immu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161308(CHEMBL179118 | [3-Aminooxalyl-1-(2-fluoro-benzyl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420904(CHEMBL2087550)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161293((3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydr...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161298((3-Aminooxalyl-1-benzyl-2-methyl-2,3,6,7,8,9-hexah...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161294(CHEMBL179966 | [3-Aminooxalyl-1-(3-fluoro-benzyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161305((3-Aminooxalyl-1-cyclohexylmethyl-2-methyl-2,3-dih...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161296((3-Aminooxalyl-1-benzyl-2-ethyl-2,3,6,7,8,9-hexahy...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420906(CHEMBL2087552)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161299((3-Aminooxalyl-1-benzyl-2-ethyl-1,6,7,8-tetrahydro...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420908(CHEMBL2087554)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420909(CHEMBL2087555)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161298((3-Aminooxalyl-1-benzyl-2-methyl-2,3,6,7,8,9-hexah...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420905(CHEMBL2087551)
Affinity DataIC50:  16nMAssay Description:Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161296((3-Aminooxalyl-1-benzyl-2-ethyl-2,3,6,7,8,9-hexahy...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084829(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  17nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50084834(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  19nMAssay Description:Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420916(CHEMBL2087562)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50420912(CHEMBL2087558)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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