BindingDB PrimarySearch_ki

Found 25 with Last Name = 'talreja' and Initial = 's'

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL

PNG

BDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)

Ki: 0.170nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL

PNG

BDBM50365964(CHEMBL1956235 | CHEMBL2070530)

Ki: 1.18nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM124444(US8759532, 99)

IC50: 0.100nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM124447(US8759532, 103)

IC50: 0.100nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: 0.100nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL

PNG

BDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)

IC50: 0.5nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50389801(CHEMBL2070528)

IC50: 0.800nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497975(CHEMBL3319207)

IC50: 0.800nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50365964(CHEMBL1956235 | CHEMBL2070530)

IC50: 1.90nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL

PNG

BDBM50365964(CHEMBL1956235 | CHEMBL2070530)

IC50: 3.47nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50494199(CHEMBL3086091)

IC50: 4.5nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50494193(CHEMBL3086099)

IC50: 5.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50389800(CHEMBL2070529)

IC50: 5.70nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair

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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE11 (unknown origin)More data for this Ligand-Target Pair

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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A/8B(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE8 (unknown origin)More data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL

PNG

BDBM50365964(CHEMBL1956235 | CHEMBL2070530)

Kd: 0.940nMAssay Description:Binding affinity to PDE10A in Sprague-Dawley rat striatum by TopCount analysisMore data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

PNG

BDBM50365964(CHEMBL1956235 | CHEMBL2070530)

Kd: 1.20nMAssay Description:Binding affinity to human truncated CM5-labeled PDE10A by surface plasmon resonance methodMore data for this Ligand-Target Pair

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Filter my 25 hits

Targets 11▿
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 15
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A/8B 1
- O43924/P16499/P18545/P35913/P51160/Q13956 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C 1
Publications 2▿
- J Med Chem 57: 6632-41 (2014) 16
- J Med Chem 55: 4776-87 (2012) 9
Institutions 1▿
- Amgen 25
Affinity: 0.10 to 3.0E+4 nM▿
- Ki 2
- IC50 21
- Kd 2
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 3