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Found 384 with Last Name = 'traquandi' and Initial = 'g'
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31541(pyrazolo[4,3-h]quinazoline-3-carboxamide, 24)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307546(CHEMBL598401 | Ethyl 4-[(3-Carbamoyl-1-methyl-4,5-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307543(1-Methyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7111((2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-oxo...)
Affinity DataIC50:  2nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307522(8-(Cyclopentylamino)-1-methyl-4,5-dihydro-1H-pyraz...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7107((2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-oxo...)
Affinity DataIC50:  2nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31539(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31532(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7163(3-Phenylacetamidoaminopyrazole deriv. 40 | CS10 | ...)
Affinity DataIC50:  3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7159(3-Phenylacetamidoaminopyrazole deriv. 36 | N-(5-Cy...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307545(1-Methyl-8-{[1-(phenylsulfonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307520(8-(Cyclohexylamino)-1-methyl-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7162(3-Phenylacetamidoaminopyrazole deriv. 39 | 4 -{2-[...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307538(8-(Cyclopentylamino)-1-(4-sulfamoylphenyl)-4,5-dih...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307509(CHEMBL592272 | N-1-Dimethyl-8-{[1-(phenylsulfonyl)...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307529(8-(Cyclopentylamino)-1-(2,2,2-trifluoroethyl)-4,5-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307530(8-(Cyclopentylamino)-1-(1-methylpiperidin-4-yl)-4,...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307553(8-(Cyclopentylamino)-1-(4-methoxyphenyl)-4,5-dihyd...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307550(1-(1-Acetylpiperidin-4-yl)-8-(cyclopentylamino)-4,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307516(8-(Cyclopentylamino)-1-(2-hydroxyethyl)-4,5-dihydr...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7160(3-Phenylacetamidoaminopyrazole deriv. 37 | N-(5-Cy...)
Affinity DataIC50:  9nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7161(3-Phenylacetamidoaminopyrazole deriv. 38 | 4 -{2-[...)
Affinity DataIC50:  11nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7114(3-Aminopyrazole deriv. 27 | N-(5-Cyclopropyl-1H-py...)
Affinity DataIC50:  11nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307515(1-Methyl-8-({1-[(4-methylpiperazin-1-yl)carbonyl]p...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7121(3-Aminopyrazole deriv. 36 | N-(5-Cyclopropyl-1H-py...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307539(8-{[4-(Acetylamino)benzyl]amino}-1-methyl-4,5-dihy...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31542(pyrazolo[4,3-h]quinazoline-3-carboxamide, 25)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307544(1-Methyl-8-{[4-(4-methylpiperazin-1-yl)benzyl]amin...)
Affinity DataIC50:  17nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7112(3-Aminopyrazole deriv. 25 | N-(5-cyclopropyl-1H-py...)
Affinity DataIC50:  17nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7118((2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(3-met...)
Affinity DataIC50:  17nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31544(pyrazolo[4,3-h]quinazoline-3-carboxamide, 27)
Affinity DataIC50:  17nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307513(8-[(2-Hydroxyethyl)amino]-1-methyl-4,5-dihydro-1H-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31533(pyrazolo[4,3-h]quinazoline-3-carboxamide, 16)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307511(8-(Cyclopentylamino)-1-phenyl-4,5-dihydro-1H-pyraz...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7103(1-(4-{1-[(5-cyclopropyl-1H-pyrazol-3-yl)carbamoyl]...)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7120((2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-oxo...)
Affinity DataIC50:  20nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307552(1-Methyl-8-[(pyridin-3-ylmethyl)amino]-4,5-dihydro...)
Affinity DataIC50:  21nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307549(1-Methyl-8-[(pyridin-4-ylmethyl)amino]-4,5-dihydro...)
Affinity DataIC50:  21nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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