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Found 122 with Last Name = 'tupper' and Initial = 'de'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132686(CHEMBL326466 | Dimethyl-((2S,3S)-3-naphthalen-2-yl...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132687(CHEMBL324269 | [(2S,3S)-3-(6-Fluoro-naphthalen-2-y...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132685(CHEMBL109571 | Dimethyl-(3-naphthalen-2-yl-bicyclo...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132678(CHEMBL432022 | [(2S,3S)-3-(6-Fluoro-naphthalen-2-y...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132684(CHEMBL331799 | Methyl-(3-naphthalen-2-yl-bicyclo[2...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(CHEMBL109517 | Dimethyl-((2R,3R)-3-naphthalen-2-yl...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity of compound against histamine H1 neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132683(6-((2S,3S)-3-Dimethylaminomethyl-bicyclo[2.2.1]hep...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  7nMAssay Description:In vitro binding affinity of compound against histamine H1 neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)
Affinity DataKi:  7.20nMAssay Description:In vitro inhibition of [3H]-NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-ben...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity of compound against neuronal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails Article
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity of compound against neuronal 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  12nMAssay Description:In vitro binding affinity of compound against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132680(CHEMBL322348 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  15nMAssay Description:In vitro binding affinity of compound against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity of compound against neuronal 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132685(CHEMBL109571 | Dimethyl-(3-naphthalen-2-yl-bicyclo...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  20nMAssay Description:In vitro binding affinity of compound against neuronal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  22nMAssay Description:In vitro binding affinity of compound against neuronal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-ben...)
Affinity DataKi:  22nMAssay Description:In vitro binding affinity of compound against histamine H1 neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-ben...)
Affinity DataKi:  23nMAssay Description:In vitro binding affinity of compound against neuronal 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132686(CHEMBL326466 | Dimethyl-((2S,3S)-3-naphthalen-2-yl...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132681(CHEMBL323678 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132684(CHEMBL331799 | Methyl-(3-naphthalen-2-yl-bicyclo[2...)
Affinity DataKi:  25nMAssay Description:In vitro inhibition of DA re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682(CHEMBL113136 | [(2S,3S)-3-(3-Chloro-phenyl)-bicycl...)
Affinity DataKi:  25nMAssay Description:In vitro ability of compound to inhibit 5-HT re-uptake of radiolabelled [3H]-tritium trasmitter into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(CHEMBL109517 | Dimethyl-((2R,3R)-3-naphthalen-2-yl...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132683(6-((2S,3S)-3-Dimethylaminomethyl-bicyclo[2.2.1]hep...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132687(CHEMBL324269 | [(2S,3S)-3-(6-Fluoro-naphthalen-2-y...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132683(6-((2S,3S)-3-Dimethylaminomethyl-bicyclo[2.2.1]hep...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682(CHEMBL113136 | [(2S,3S)-3-(3-Chloro-phenyl)-bicycl...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132688(CHEMBL323447 | Dimethyl-(3-naphthalen-1-yl-bicyclo...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132680(CHEMBL322348 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682(CHEMBL113136 | [(2S,3S)-3-(3-Chloro-phenyl)-bicycl...)
Affinity DataKi:  64nMAssay Description:In vitro inhibition of DA re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132681(CHEMBL323678 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289291(2-Hydroxy-methylolanzapine | CHEMBL100454 | [10-(4...)
Affinity DataKi:  66nMAssay Description:In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  68nMAssay Description:In vitro binding affinity of compound against muscarinic neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132681(CHEMBL323678 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132678(CHEMBL432022 | [(2S,3S)-3-(6-Fluoro-naphthalen-2-y...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-ben...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity of compound against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289292(2-Methyl-10-(4-methyl-4-oxy-piperazin-1-yl)-4H-3-t...)
Affinity DataKi:  87nMAssay Description:In vitro binding affinity of compound against histamine H1 neuronal receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataKi:  99nMAssay Description:Compound was tested for its ability to displace [3H]-citalopram from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132685(CHEMBL109571 | Dimethyl-(3-naphthalen-2-yl-bicyclo...)
Affinity DataKi:  111nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289292(2-Methyl-10-(4-methyl-4-oxy-piperazin-1-yl)-4H-3-t...)
Affinity DataKi:  112nMAssay Description:In vitro binding affinity of compound against neuronal 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289292(2-Methyl-10-(4-methyl-4-oxy-piperazin-1-yl)-4H-3-t...)
Affinity DataKi:  119nMAssay Description:In vitro binding affinity of compound against neuronal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  119nMAssay Description:In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132680(CHEMBL322348 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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