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Found 86 with Last Name = 'wallis' and Initial = 'ng'
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573875(CHEMBL4869086)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417999(US10457669, Example 675 | US11001575, Example 675)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573874(CHEMBL4873851)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418019(US10457669, Example 698 | US11001575, Example 698)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418270((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418018(US10457669, Example 697 | US11001575, Example 697)
Affinity DataIC50:  2nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456355(CHEMBL4207147 | US11001575, Example 554)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human A375 cells harboring BRAF V600E mutant after 4 hrs by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456356(CHEMBL4209691 | US11001575, Example 674)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573872(CHEMBL4868536)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418007(US10457669, Example 1083 | US10457669, Example 685...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418315((2R)-2-(3-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50:  3nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418226((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573873(CHEMBL4870176)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456353(CHEMBL4210682 | US11001575, Example 2)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456347(CHEMBL4207117 | US11001575, Example 80)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456351(CHEMBL4217740 | US11001575, Example 103)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456361(CHEMBL4215376 | US11001575, Example 141)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417431(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456362(CHEMBL4206693 | US11001575, Example 35)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456346(CHEMBL4204392 | US11001575, Example 128)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418281((2R)-2-[6-(5-chloro-2-{[(2S)-1- hydroxypropan-2-yl...)
Affinity DataIC50:  12nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417432(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50:  20nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataIC50:  20nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456352(CHEMBL4213926 | US11001575, Example 104)
Affinity DataIC50:  21nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456350(CHEMBL4207587 | US11001575, Example 132)
Affinity DataIC50:  24nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  25nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417517(N-benzyl-2-(6-{5-chloro- 2-[(oxan-4-yl)amino] pyri...)
Affinity DataIC50:  25nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456358(CHEMBL4213466 | US11001575, Example 77)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456358(CHEMBL4213466 | US11001575, Example 77)
Affinity DataIC50:  26nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  30nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147422(3-(4-Chloro-1-guanidino-isoquinolin-7-yl)-benzoic ...)
Affinity DataIC50:  37nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456359(CHEMBL4206737 | US11001575, Example 409)
Affinity DataIC50:  40nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8734((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  50nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8732((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)
Affinity DataIC50:  50nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Glaxosmithkline

LigandPNGBDBM8734((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50: <60nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  60nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456354(CHEMBL4202882 | US11001575, Example 410)
Affinity DataIC50:  68nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Glaxosmithkline

LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50: <70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Glaxosmithkline

LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
Glaxosmithkline

LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50:  70nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231528(4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-(piperidi...)
Affinity DataIC50:  72nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  130nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
Glaxosmithkline

LigandPNGBDBM8734((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  130nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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