Affinity DataKi: 0.25nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Affinity DataKi: 340nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) preincubated with compound for 20 mins followed by substrate addition measured after 120 mins in presence of...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of IRE1alpha (unknown origin) assessed as XBP-1 slicing luciferase activity incubated for 1 hr followed by stimulation with thapsigargin m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of IRE1alpha (unknown origin) assessed as XBP-1 slicing luciferase activity incubated for 1 hr followed by stimulation with thapsigargin m...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of IRE1alpha (unknown origin) assessed as XBP-1 slicing luciferase activity incubated for 1 hr followed by stimulation with thapsigargin m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma
Curated by ChEMBL
Paraza Pharma
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair