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Found 737 with Last Name = 'wells' and Initial = 'km'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394718(CHEMBL2165801)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394722(CHEMBL2165807)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394717(CHEMBL2165802)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394718(CHEMBL2165801)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394719(CHEMBL2165800)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394720(CHEMBL2165799)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394721(CHEMBL2165808)
Affinity DataKi:  1.40nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394716(CHEMBL2165803)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394717(CHEMBL2165802)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394715(CHEMBL2165804)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394722(CHEMBL2165807)
Affinity DataKi:  2.40nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394719(CHEMBL2165800)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394723(CHEMBL2165806)
Affinity DataKi:  3.10nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50330987(2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-inde...)
Affinity DataKi:  4.10nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50330987(2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-inde...)
Affinity DataKi:  4.10nMAssay Description:Antagonist activity at adenosine A2A receptorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394721(CHEMBL2165808)
Affinity DataKi:  5.20nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394720(CHEMBL2165799)
Affinity DataKi:  6nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316887(2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[...)
Affinity DataKi:  6.5nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316876(2-amino-8-(4-methylpiperazine-1-carbonyl)-4-phenyl...)
Affinity DataKi:  8.20nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394715(CHEMBL2165804)
Affinity DataKi:  9nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394724(CHEMBL2165805)
Affinity DataKi:  13.1nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50330987(2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-inde...)
Affinity DataKi:  17nMAssay Description:Antagonist activity at adenosine A1 receptorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50330987(2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-inde...)
Affinity DataKi:  17nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394716(CHEMBL2165803)
Affinity DataKi:  29.3nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394724(CHEMBL2165805)
Affinity DataKi:  37.3nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316887(2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[...)
Affinity DataKi:  48.2nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316876(2-amino-8-(4-methylpiperazine-1-carbonyl)-4-phenyl...)
Affinity DataKi:  58.4nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394723(CHEMBL2165806)
Affinity DataKi:  223nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248583(US9434711, 496)
Affinity DataIC50:  0.183nMAssay Description:For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50036555(CHEMBL3353610 | US9434711, 497)
Affinity DataIC50:  0.400nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248583(US9434711, 496)
Affinity DataIC50:  0.554nMAssay Description:For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248576(US9434711, 489)
Affinity DataIC50:  0.600nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248370(US9434711, 227)
Affinity DataIC50:  0.600nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248838(US9434711, 808)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248599(US9434711, 518)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248480(US9434711, 361)
Affinity DataIC50:  0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248426(US9434711, 292)
Affinity DataIC50:  0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248580(US9434711, 493)
Affinity DataIC50:  0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50:  0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248583(US9434711, 496)
Affinity DataIC50:  0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248581(US9434711, 494)
Affinity DataIC50:  0.900nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248789(US9434711, 755)
Affinity DataIC50:  0.900nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248389(US9434711, 249)
Affinity DataIC50:  0.900nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248367(US9434711, 224)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248458(US9434711, 335)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248840(US9434711, 810)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248414(US9434711, 278)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248578(US9434711, 491)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248613(US9434711, 535)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM248607(US9434711, 526)
Affinity DataIC50:  1nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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