Compile Data Set for Download or QSAR
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TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM8885(Testosterone, 1 | (1S,2R,10R,11S,14S,15S)-14-hydro...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.520nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 278 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.560nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 283 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.610nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 273 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.680nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 288 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.740nMAssay Description:Dissociation constant value of the radiolabeled compound against the androgen receptor 293 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.990nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 298 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataKd:  1nMAssay Description:Agonist activity at human Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  1.21nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 303 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50131272(3-(4-Fluoro-phenyl)-4-[1-(4-pyrrolidin-1-yl-phenyl...)
Affinity DataKd:  1.40nMAssay Description:Dissociation constant against GST-hARLBD was measured in SC-3 cell by using [3H]testosterone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50131269(3-(2-Fluoro-phenyl)-4-[1-(4-pyrrolidin-1-yl-phenyl...)
Affinity DataKd:  1.40nMAssay Description:Dissociation constant against GST-hARLBD was measured in SC-3 cell by using [3H]testosterone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50131271(3-(4-Hydroxy-phenyl)-4-[1-(4-pyrrolidin-1-yl-pheny...)
Affinity DataKd:  1.40nMAssay Description:Dissociation constant against GST-hARLBD was measured in SC-3 cell by using [3H]testosterone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50131268(4-[1-(4-Dibutylamino-phenyl)-meth-(Z)-ylidene]-3-p...)
Affinity DataKd:  1.40nMAssay Description:Dissociation constant against GST-hARLBD was measured in SC-3 cell by using [3H]testosterone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  1.51nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 308 KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  1.95nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 310KMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334273(2-Butyl-2- hydroxy-hexanoic acid (2-bromo- pyridin...)
Affinity DataKd:  15nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334276(2-Hydroxy-2,4- dimethyl-pentanoic acid (2-bromo-6-...)
Affinity DataKd:  20nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334272(2-Hydroxy-2- methyl-hexanoic acid (2-bromo- 6-meth...)
Affinity DataKd:  30nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334271(2-Hydroxy-2- methyl- pentanoic acid (2-bromo-pyrid...)
Affinity DataKd:  75nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334275(N-(2-Bromo- pyridin-4-yl)-2- hydroxy-2-phenyl- pro...)
Affinity DataKd:  100nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334277(N-(2-Bromo-pyridin- 4-yl)-2-hydroxy- 2-methyl-4-ph...)
Affinity DataKd:  100nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334274(N-(2-Bromo-pyridin- 4-yl)-2-hydroxy-4- (4-methoxy-...)
Affinity DataKd:  300nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50529667(CHEMBL4444904 | US10806720, Compound 11 | US112305...)
Affinity DataKd:  1.30E+3nMAssay Description:Inhibition of androgen receptor AF1 domain (141 to 486 residues) (unknown origin) incubated for 30 mins by steady-state fluorescence emission spectro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor [646-919](Human)
Karlsruhe Institute of Technology

LigandPNGBDBM227645(MAQRGGARRPRGDRERLGSR | Bag-1L (1-20))
Affinity DataKd:  2.00E+3nMpH: 6.5Assay Description:For the fluorescence polarization experiments, 5 nM fluorescently labeled Bag-1L (Bag-1L(1-20), fluorescein isothiocyanate (FITC)-MAQRGGARRPRGDRERLGS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor [646-919](Human)
Karlsruhe Institute of Technology

LigandPNGBDBM227647(HDSKGQTKLLQLLTTKSDQM | SCR-2 peptide)
Affinity DataKd:  2.80E+3nMpH: 6.5Assay Description:For the fluorescence polarization experiments, 5 nM fluorescently labeled Bag-1L (Bag-1L(1-20), fluorescein isothiocyanate (FITC)-MAQRGGARRPRGDRERLGS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor [646-919](Human)
Karlsruhe Institute of Technology

LigandPNGBDBM227646(RGAAAGARRPRMKKKTRRRS | Bag-1L (61-80))
Affinity DataKd:  3.30E+3nMpH: 6.5Assay Description:For the fluorescence polarization experiments, 5 nM fluorescently labeled Bag-1L (Bag-1L(1-20), fluorescein isothiocyanate (FITC)-MAQRGGARRPRGDRERLGS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM334278(4-(2-Hydroxy-2- methyl- pentanoylamino)- pyridine-...)
Affinity DataKd:  6.00E+3nMAssay Description:The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataKd:  6.52E+3nMAssay Description:Binding affinity to full length androgen receptor (unknown origin) assessed as dissociation constant at 5 uM measured after 15 mins by biolayer inter...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50589959(CHEMBL5203294)
Affinity DataKd:  8.99E+3nMAssay Description:Binding affinity to full length androgen receptor (unknown origin) assessed as dissociation constant at 5 uM measured after 15 mins by biolayer inter...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50589954(CHEMBL5177079)
Affinity DataKd:  1.01E+4nMAssay Description:Binding affinity to full length androgen receptor (unknown origin) assessed as dissociation constant at 5 uM measured after 15 mins by biolayer inter...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50589964(CHEMBL5201101)
Affinity DataKd:  2.05E+4nMAssay Description:Binding affinity to full length androgen receptor (unknown origin) assessed as dissociation constant at 5 uM measured after 15 mins by biolayer inter...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataKd:  4.02E+4nMAssay Description:Binding affinity to human AR LBD (663 to 920 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by biolayer interfe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50584670(CHEMBL5085066)
Affinity DataKd:  7.59E+4nMAssay Description:Binding affinity to human AR LBD (663 to 920 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant in presence of DHT ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataKd:  2.95E+5nMAssay Description:Binding affinity to human AR LBD (663 to 920 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant in presence of DHT ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50584670(CHEMBL5085066)
Affinity DataKd:  7.60E+7nMAssay Description:Binding affinity to human AR LBD (663 to 920 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by biolayer interfe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed