Compile Data Set for Download or QSAR
maximum 50k data
Found 45 of ic50 for UniProtKB: Q9UQM7
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.0310nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: >1nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430016(CHEMBL2335444)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430015(CHEMBL2335442)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430014(CHEMBL2335479)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748((E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethen...)
Affinity DataIC50:  290nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  680nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520464(CHEMBL4556306)
Affinity DataIC50:  790nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520463(CHEMBL4572769)
Affinity DataIC50:  810nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520462(CHEMBL4515601)
Affinity DataIC50:  840nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50095952(CHEMBL3593777)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CaMK2a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50611755(CHEMBL5281283)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CAMK2alpha (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748((E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethen...)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50228744(5-Hydroxy-Diclofenac | CHEBI:59612)
Affinity DataIC50:  1.81E+3nMAssay Description:Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fl...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50563780(CHEMBL4795714)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of wild-type human CAMK2alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748((E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethen...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748((E)-3,5-Bis[beta-(4-Hydroxy-3-methoxyphenyl)-ethen...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM236557(US9365572, 5)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50427874(CHEMBL2324596)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human alphaCaMK2 by CaM kinase 2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length human CaMK2alpha using KKLNRTLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33ATP] by radiome...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50235817(CHEMBL4078893)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50235820(CHEMBL4066664)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50235816(CHEMBL4069365)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CAMK2alpha using [KKLNRTLSFAEPG] as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163744((1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163745(4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-...)
Affinity DataIC50:  2.44E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50059989((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CAMK2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50:  1.11E+5nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50588629(CHEMBL5170093)
Affinity DataIC50:  4.52E+5nMAssay Description:Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fl...More data for this Ligand-Target Pair
In DepthDetails PubMed