Compile Data Set for Download or QSAR
maximum 50k data
Found 383 of ic50 for UniProtKB: P29350
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  0.335nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50:  16nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50:  18nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50:  30nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50556732(CHEMBL4750435)
Affinity DataIC50:  130nMAssay Description:Inhibition of PTPN6 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50594492(CHEMBL3322530)
Affinity DataIC50:  290nMAssay Description:Inhibition of human SHP1More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50335865(6-Hydroxy-2-(4-methoxyphenyl)-3-(1-(4-(naphthalen-...)
Affinity DataIC50:  335nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  355nMAssay Description:Inhibition of recombinant GST-fused human SHP1 (205 to 597 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM152210(US8987474, NSC-87877)
Affinity DataIC50:  355nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  360nMAssay Description:Inhibition of human SHP1 catalytic domain (205 to 597 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50335867(3-(1-(4-(4-Chloronaphthalen-1-ylamino)-4-oxobutyl)...)
Affinity DataIC50:  378nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50335868(6-Hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Affinity DataIC50:  408nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50335870(6-Hydroxy-3-(1-(4-(6-methoxybenzo[d]thiazol-2-ylam...)
Affinity DataIC50:  486nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246668(3-(benzo[d][1,3]dioxol-5-yl)-2-(5-((4aR,6aS,6bR,8a...)
Affinity DataIC50:  710nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50425815(CHEMBL2316908)
Affinity DataIC50:  760nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290925(CHEMBL4175748)
Affinity DataIC50:  850nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50246745(3-(4-Carboxy-benzyloxy)-28-[4-butyric ((S)-1-carbo...)
Affinity DataIC50:  890nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50436358(CHEMBL2396718)
Affinity DataIC50:  910nMAssay Description:Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124262(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Affinity DataIC50:  1.00E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290909(CHEMBL4164960)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50054344(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)
Affinity DataIC50:  1.44E+3nMAssay Description:For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50054344(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512277(CHEMBL4445615)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50546233(CHEMBL4757579)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP1 (222 to 535 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM124261(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50:  1.90E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50546232(CHEMBL4762771)
Affinity DataIC50:  2.08E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50546229(CHEMBL4780471)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50425808(CHEMBL2316906)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50425807(CHEMBL2316902)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50133021(CHEMBL3634592)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50096222(CHEMBL3593818)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351780(CHEMBL1823762)
Affinity DataIC50:  2.43E+3nMpH: 8.0Assay Description:Inhibition of human recombinant SHP1 in Tris buffer at pH 8 using OMPF as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184997(CHEMBL3822604)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of human SHP1 using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50425806(CHEMBL2316907)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124264(Bis(4-nitro-2-((phenylimino)methyl)phenolate)-oxov...)
Affinity DataIC50:  2.50E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50526048(CHEMBL4536323)
Affinity DataIC50:  2.54E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50425816(CHEMBL2316910)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50530578(CHEMBL4452781)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530581(CHEMBL4444045)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530580(CHEMBL4446933)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530579(CHEMBL4452883)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530581(CHEMBL4444045)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530580(CHEMBL4446933)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50530579(CHEMBL4452883)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 383 total ) | Next | Last >>
Jump to: