Compile Data Set for Download or QSAR
Found 23 Enz. Inhib. hit(s) with all data for entry = 50029750
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287527(6-(2-Isopropyl-benzenesulfonyl)-5-nitro-quinolin-8...)
Show SMILES CC(C)c1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C18H17N3O4S/c1-11(2)12-6-3-4-8-15(12)26(24,25)16-10-14(19)17-13(7-5-9-20-17)18(16)21(22)23/h3-11H,19H2,1-2H3
Affinity DataKi:  48nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287536(6-(2-Fluoro-benzenesulfonyl)-5-nitro-quinolin-8-yl...)
Show SMILES Nc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C15H10FN3O4S/c16-10-5-1-2-6-12(10)24(22,23)13-8-11(17)14-9(4-3-7-18-14)15(13)19(20)21/h1-8H,17H2
Affinity DataKi:  58nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287529(6-(2-Chloro-benzenesulfonyl)-5-nitro-quinolin-8-yl...)
Show SMILES Nc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C15H10ClN3O4S/c16-10-5-1-2-6-12(10)24(22,23)13-8-11(17)14-9(4-3-7-18-14)15(13)19(20)21/h1-8H,17H2
Affinity DataKi:  93nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287541(5-Nitro-6-(toluene-2-sulfonyl)-quinolin-8-ylamine ...)
Show SMILES Cc1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4S/c1-10-5-2-3-7-13(10)24(22,23)14-9-12(17)15-11(6-4-8-18-15)16(14)19(20)21/h2-9H,17H2,1H3
Affinity DataKi:  119nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287538(6-(2-Ethyl-benzenesulfonyl)-5-nitro-quinolin-8-yla...)
Show SMILES CCc1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O4S/c1-2-11-6-3-4-8-14(11)25(23,24)15-10-13(18)16-12(7-5-9-19-16)17(15)20(21)22/h3-10H,2,18H2,1H3
Affinity DataKi:  129nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287534(6-(2-Bromo-benzenesulfonyl)-5-nitro-quinolin-8-yla...)
Show SMILES Nc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1Br
Show InChI InChI=1S/C15H10BrN3O4S/c16-10-5-1-2-6-12(10)24(22,23)13-8-11(17)14-9(4-3-7-18-14)15(13)19(20)21/h1-8H,17H2
Affinity DataKi:  234nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287526(6-(4-Amino-benzenesulfonyl)-5-nitro-quinolin-8-yla...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C15H12N4O4S/c16-9-3-5-10(6-4-9)24(22,23)13-8-12(17)14-11(2-1-7-18-14)15(13)19(20)21/h1-8H,16-17H2
Affinity DataKi:  282nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287539(6-Benzenesulfonyl-5-nitro-quinolin-8-ylamine | CHE...)
Show SMILES Nc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H11N3O4S/c16-12-9-13(23(21,22)10-5-2-1-3-6-10)15(18(19)20)11-7-4-8-17-14(11)12/h1-9H,16H2
Affinity DataKi:  297nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287530(5-Nitro-6-(toluene-4-sulfonyl)-quinolin-8-ylamine ...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4S/c1-10-4-6-11(7-5-10)24(22,23)14-9-13(17)15-12(3-2-8-18-15)16(14)19(20)21/h2-9H,17H2,1H3
Affinity DataKi:  594nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287525(6-(3-Chloro-benzenesulfonyl)-5-nitro-quinolin-8-yl...)
Show SMILES Nc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H10ClN3O4S/c16-9-3-1-4-10(7-9)24(22,23)13-8-12(17)14-11(5-2-6-18-14)15(13)19(20)21/h1-8H,17H2
Affinity DataKi:  892nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287528(6-(4-Methoxy-benzenesulfonyl)-5-nitro-quinolin-8-y...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O5S/c1-24-10-4-6-11(7-5-10)25(22,23)14-9-13(17)15-12(3-2-8-18-15)16(14)19(20)21/h2-9H,17H2,1H3
Affinity DataKi:  1.14E+3nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287533(6-(4-Amino-benzenesulfinyl)-5-nitro-quinolin-8-yla...)
Show SMILES Nc1ccc(cc1)S(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C15H12N4O3S/c16-9-3-5-10(6-4-9)23(22)13-8-12(17)14-11(2-1-7-18-14)15(13)19(20)21/h1-8H,16-17H2
Affinity DataKi:  1.25E+3nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287532(6-(4-Chloro-benzenesulfonyl)-5-nitro-quinolin-8-yl...)
Show SMILES Nc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClN3O4S/c16-9-3-5-10(6-4-9)24(22,23)13-8-12(17)14-11(2-1-7-18-14)15(13)19(20)21/h1-8H,17H2
Affinity DataKi:  1.75E+3nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287540(CHEMBL54289 | N-(8-Amino-5-nitro-quinolin-6-yl)-be...)
Show SMILES Nc1cc(NS(=O)(=O)c2ccccc2)c([N+]([O-])=O)c2cccnc12
Show InChI InChI=1S/C15H12N4O4S/c16-12-9-13(18-24(22,23)10-5-2-1-3-6-10)15(19(20)21)11-7-4-8-17-14(11)12/h1-9,18H,16H2
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287537(6-(4-Amino-phenylsulfanyl)-5-nitro-quinolin-8-ylam...)
Show SMILES Nc1ccc(Sc2cc(N)c3ncccc3c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C15H12N4O2S/c16-9-3-5-10(6-4-9)22-13-8-12(17)14-11(2-1-7-18-14)15(13)19(20)21/h1-8H,16-17H2
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287535(4-(5-Nitro-quinoline-6-sulfonyl)-phenylamine | CHE...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C15H11N3O4S/c16-10-3-5-11(6-4-10)23(21,22)14-8-7-13-12(2-1-9-17-13)15(14)18(19)20/h1-9H,16H2
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287531((6-Benzenesulfonyl-5-nitro-quinolin-8-yl)-methyl-a...)
Show SMILES CNc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H13N3O4S/c1-17-13-10-14(24(22,23)11-6-3-2-4-7-11)16(19(20)21)12-8-5-9-18-15(12)13/h2-10,17H,1H3
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50287526(6-(4-Amino-benzenesulfonyl)-5-nitro-quinolin-8-yla...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C15H12N4O4S/c16-9-3-5-10(6-4-9)24(22,23)13-8-12(17)14-11(2-1-7-18-14)15(13)19(20)21/h1-8H,16-17H2
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y2 (NPY2) receptor from rat hippocampi.More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287524(6-(4-Amino-benzenesulfonyl)-quinolin-8-ylamine | C...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1cc(N)c2ncccc2c1
Show InChI InChI=1S/C15H13N3O2S/c16-11-3-5-12(6-4-11)21(19,20)13-8-10-2-1-7-18-15(10)14(17)9-13/h1-9H,16-17H2
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287542(6-Methanesulfonyl-5-nitro-quinolin-8-ylamine | CHE...)
Show SMILES CS(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C10H9N3O4S/c1-18(16,17)8-5-7(11)9-6(3-2-4-12-9)10(8)13(14)15/h2-5H,11H2,1H3
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287522(6-(4-Amino-benzenesulfonyl)-quinoline-5,8-diamine ...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1cc(N)c2ncccc2c1N
Show InChI InChI=1S/C15H14N4O2S/c16-9-3-5-10(6-4-9)22(20,21)13-8-12(17)15-11(14(13)18)2-1-7-19-15/h1-8H,16-18H2
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287523(6-Benzenesulfonyl-8-methyl-5-nitro-quinoline | CHE...)
Show SMILES Cc1cc(c([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H12N2O4S/c1-11-10-14(23(21,22)12-6-3-2-4-7-12)16(18(19)20)13-8-5-9-17-15(11)13/h2-10H,1H3
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50287527(6-(2-Isopropyl-benzenesulfonyl)-5-nitro-quinolin-8...)
Show SMILES CC(C)c1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+]([O-])=O
Show InChI InChI=1S/C18H17N3O4S/c1-11(2)12-6-3-4-8-15(12)26(24,25)16-10-14(19)17-13(7-5-9-20-17)18(16)21(22)23/h3-11H,19H2,1-2H3
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for binding affinity against neuropeptide Y2 (NPY2) receptor from rat hippocampi.More data for this Ligand-Target Pair