Compile Data Set for Download or QSAR
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Found 680 Enz. Inhib. hit(s) with Target = 'Trypanothione reductase'
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50240622(3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydr...)
Affinity DataKi:  76nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093208(2-(5-Bromo-1H-indol-3-yl)-N-[3-(4-{3-[2-(5-bromo-1...)
Affinity DataKi:  76nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091160(CHEMBL106127 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178811(CHEMBL199020 | N-(3-aminopropyl)-4-tert-butyl-N,N-...)
Affinity DataKi:  150nMAssay Description:Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096495(CHEMBL85161 | N-{3-[Bis-(3-phenyl-propyl)-amino]-p...)
Affinity DataKi:  151nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178803(3,4-dichloro-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  180nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataKi:  190nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50103373(CHEMBL3398189)
Affinity DataKi:  255nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction of trypanothione disulfide by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataKi:  270nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093209(2-(5-Methoxy-1H-indol-3-yl)-N-[3-(4-{3-[2-(5-metho...)
Affinity DataKi:  280nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354299(CHEMBL1836378)
Affinity DataKi:  320nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093210(3-(1H-Indol-3-yl)-N-(3-{4-[3-(2-1H-indol-3-yl-acet...)
Affinity DataKi:  350nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093205(2-(1H-Indol-3-yl)-N-(3-{4-[3-(2-1H-indol-3-yl-acet...)
Affinity DataKi:  390nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM10469(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of Trypanosoma cruzi trypanothione reductase using varying levels of trypanothione disulfide as substrate by Lineweaver--burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178803(3,4-dichloro-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  440nMAssay Description:Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354257(CHEMBL1836559)
Affinity DataKi:  440nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091158(CHEMBL322826 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091165((4-Benzyloxy-benzyl)-[3-(2-chloro-phenothiazin-10-...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Leishmania infantum)
Instituto de Qu£mica M£dica (IQM-CSIC)

Curated by ChEMBL
LigandPNGBDBM50571699(CHEMBL4855840)
Affinity DataKi:  500nMAssay Description:Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 12.5 uM TS2 by DTNB-reagent based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Leishmania infantum)
Instituto de Qu£mica M£dica (IQM-CSIC)

Curated by ChEMBL
LigandPNGBDBM50571699(CHEMBL4855840)
Affinity DataKi:  500nMAssay Description:Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 6.2 uM TS2 by DTNB-reagent based s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091148(CHEMBL106769 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178809(4-tert-butyl-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  570nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Leishmania infantum)
Instituto de Qu£mica M£dica (IQM-CSIC)

Curated by ChEMBL
LigandPNGBDBM50571699(CHEMBL4855840)
Affinity DataKi:  600nMAssay Description:Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 3.1 uM TS2 by DTNB-reagent based s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096500(CHEMBL86281 | N,N'-Bis-(3-phenyl-propyl)-N,N'-bis-...)
Affinity DataKi:  614nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091162((4-tert-Butyl-benzyl)-[3-(2-chloro-phenothiazin-10...)
Affinity DataKi:  680nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091163(Benzhydryl-[3-(2-chloro-phenothiazin-10-yl)-propyl...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093206(CHEMBL78036 | Spermine derivative)
Affinity DataKi:  750nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091154(CHEMBL106901 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  770nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Leishmania infantum)
Instituto de Qu£mica M£dica (IQM-CSIC)

Curated by ChEMBL
LigandPNGBDBM50571699(CHEMBL4855840)
Affinity DataKi:  800nMAssay Description:Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 25 uM TS2 by DTNB-reagent based sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093211(CHEMBL308396 | Spermine derivative)
Affinity DataKi:  850nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50019879(CHEMBL279905 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091157((2-Adamantan-1-yl-2-oxo-ethyl)-[3-(2-chloro-phenot...)
Affinity DataKi:  1.23E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093204(4-(1H-Indol-3-yl)-N-(3-{4-[3-(4-1H-indol-3-yl-buty...)
Affinity DataKi:  1.26E+3nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Leishmania infantum)
Instituto de Qu£mica M£dica (IQM-CSIC)

Curated by ChEMBL
LigandPNGBDBM50571699(CHEMBL4855840)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 100 uM TS2 by DTNB-reagent based s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091153(Benzyl-[3-(2-chloro-phenothiazin-10-yl)-propyl]-di...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096491(CHEMBL85189 | N-(3-Amino-propyl)-N,N'-bis-(3-pheny...)
Affinity DataKi:  1.38E+3nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093207((E)-3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[(E)-3-(3,...)
Affinity DataKi:  1.39E+3nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Leishmania infantum)
Instituto de Qu£mica M£dica (IQM-CSIC)

Curated by ChEMBL
LigandPNGBDBM50571699(CHEMBL4855840)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 50 uM TS2 by DTNB-reagent based sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091159(CHEMBL326458 | [2-(4-Chloro-3-methyl-phenyl)-2-oxo...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataKi:  1.46E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091156((4-Bromo-benzyl)-[3-(2-chloro-phenothiazin-10-yl)-...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091155(CHEMBL323271 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.55E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091164(CHEMBL106236 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.67E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178807(3,4-dichloro-N-(3-(5-chloro-2-(phenylthio)phenylam...)
Affinity DataKi:  1.69E+3nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using (ZCG.dmapa)2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178807(3,4-dichloro-N-(3-(5-chloro-2-(phenylthio)phenylam...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of Trypanosoma cruzi recombinant trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091149((4-Chloro-benzyl)-[3-(2-chloro-phenothiazin-10-yl)...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataKi:  1.78E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Crithidia fasciculata)
Pontificia Universidad Catolica del Peru

Curated by ChEMBL
LigandPNGBDBM50240622(3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydr...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of Crithidia fasciculata free trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091150(CHEMBL323540 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50170723(1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide...)
Affinity DataKi:  2.00E+3nMpH: 7.5Assay Description:Inhibitory constant against recombinant Trypanosoma cruzi trypanothione reductase was determined photometrically at 25 degree C in TR assay buffer (4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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