Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50031842
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320340((R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320341((R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320339((R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320335((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320345((S)-(2-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320342((S)-(2-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320355(phenyl(4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320334((R)-(4-(4-(4-(dimethylamino)phenyl)phthalazin-1-yl...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320356((4-(4-(4-chlorophenyl)phthalazin-1-yl)piperazin-1-...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320361((S)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320344((S)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-2-methy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320338((R)-(4-(4-(4-isopropylphenyl)phthalazin-1-yl)-3-me...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320364((4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(thiazo...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320337((R)-(4-(4-(4-tert-butylphenyl)phthalazin-1-yl)-3-m...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320353((4-(4-(4-fluorophenyl)phthalazin-1-yl)piperazin-1-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320359((S)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320343((S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320365(furan-2-yl(4-(4-phenylphthalazin-1-yl)piperazin-1-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320360((R)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320350(phenyl(4-(4-o-tolylphthalazin-1-yl)piperazin-1-yl)...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320354((4-(4-(4-methoxyphenyl)phthalazin-1-yl)piperazin-1...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320357((4-(4-(3,4-dichlorophenyl)phthalazin-1-yl)piperazi...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320362(phenyl(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)m...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320349((4-(4-(2-chlorophenyl)phthalazin-1-yl)piperazin-1-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320352((4-(4-(3-methoxyphenyl)phthalazin-1-yl)piperazin-1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320366((4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(thioph...)
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse SMO expressed in NIH-3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320363(1-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)ethan...)
Affinity DataIC50: 91nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320346((S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)p...)
Affinity DataIC50: 96nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320348((S)-(2-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)p...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320351(3-(4-(4-benzoylpiperazin-1-yl)phthalazin-1-yl)benz...)
Affinity DataIC50: 212nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320347((S)-(2-methyl-4-(4-(pyridin-3-yl)phthalazin-1-yl)p...)
Affinity DataIC50: 213nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320368((S)-(2-methyl-4-(4-(pyridazin-1(6H)-yl)phthalazin-...)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320367((S)-(2-methyl-4-(4-(oxazol-2-yl)phthalazin-1-yl)pi...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed