Compile Data Set for Download or QSAR
Report error Found 92 Enz. Inhib. hit(s) with all data for entry = 50044305
TargetKappa-type opioid receptor(Guinea pig)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at kappa opioid receptor in guinea pig caudate assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50350976(CHEMBL1818341)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012152(CHEMBL3264441)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at mu opioid receptor in guinea pig caudate assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71610(KUC104502N | KSC-1-256 | ML190 | cid_44665680)
Affinity DataIC50: 3nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71613(KSC-1-265 | KUC104505N | cid_44665679)
Affinity DataIC50: 4nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]diprenorphine from mu opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50350976(CHEMBL1818341)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012149(CHEMBL3264446 | US9682966, 105 | US10118915, Compo...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012152(CHEMBL3264441)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]diprenorphine from mu opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataIC50: 30nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012153(zyklophin)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataIC50: 60nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71611(KSC-1-261 | KUC104503N | cid_44665687)
Affinity DataIC50: 70nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71610(KUC104502N | KSC-1-256 | ML190 | cid_44665680)
Affinity DataIC50: 120nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012150(CHEMBL3264439)
Affinity DataKi:  159nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012150(CHEMBL3264439)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]diprenorphine from mu opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71613(KSC-1-265 | KUC104505N | cid_44665679)
Affinity DataIC50: 190nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]diprenorphine from delta opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50154200(7-amino-6-methoxy-8,8-dimethyl-5,6,7,8-tetrahydron...)
Affinity DataEC50:  234nMAssay Description:Agonist activity at human cloned mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012149(CHEMBL3264446 | US9682966, 105 | US10118915, Compo...)
Affinity DataIC50: 343nMAssay Description:Antagonist activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012148(CHEMBL3183148)
Affinity DataIC50: 376nMAssay Description:Antagonist activity at human cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012150(CHEMBL3264439)
Affinity DataKi:  475nMAssay Description:Displacement of [3H]diprenorphine from delta opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71581(cid_44620907 | N-[2-[(4-bromophenyl)methyl-propan-...)
Affinity DataIC50: 570nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71581(cid_44620907 | N-[2-[(4-bromophenyl)methyl-propan-...)
Affinity DataIC50: 660nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71611(KSC-1-261 | KUC104503N | cid_44665687)
Affinity DataIC50: 690nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71619(KUC104646N | KSC-1-278 | cid_45100475)
Affinity DataIC50: 700nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataIC50: 860nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataIC50: 860nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71610(KUC104502N | KSC-1-256 | ML190 | cid_44665680)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71610(KUC104502N | KSC-1-256 | ML190 | cid_44665680)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to adrenergic alpha2C receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to muscarinic M2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM71610(KUC104502N | KSC-1-256 | ML190 | cid_44665680)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54817(N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-methy...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012152(CHEMBL3264441)
Affinity DataKi:  1.06E+3nMAssay Description:Displacement of [3H]diprenorphine from delta opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM65828(4-[[(4-ethylphenyl)sulfonylamino]methyl]-N-[2-[(ph...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by DiscoveryRx b-arrestin PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM54842(SMR000627745 | MLS001123392 | cid_22553442)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) using dynorphin A by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75566(KSC-11-114-1 | cid_45115589 | N-[2-[tert-butyl-(ph...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of mu opioid receptor (unknown origin) using DAMGO by high content imaging beta-arrestin translocation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
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