BindingDB PrimarySearch

Found 16 Enz. Inhib. hit(s) with all data for entry = 50006228

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM124447(US8759532, 103)

IC50: 0.100nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM124444(US8759532, 99)

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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497975(CHEMBL3319207)

IC50: 0.800nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50494199(CHEMBL3086091)

IC50: 4.5nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50494193(CHEMBL3086099)

IC50: 5.10nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE11 (unknown origin)More data for this Ligand-Target Pair

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O43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair

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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A/8B(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE8 (unknown origin)More data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50497974(CHEMBL3319209)

IC50: >3.00E+4nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair

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Filter my 16 hits

Targets 11▿
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 6
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A/8B 1
- O43924/P16499/P18545/P35913/P51160/Q13956 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C 1
Publications 1▿
- J Med Chem 57: 6632-41 (2014) 16
Institutions 1▿
- Amgen 16
Affinity: 0.10 to 3.0E+4 nM▿
- IC50 16
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 1