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Found 18 Enz. Inhib. hit(s) with all data for entry = 50016873
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50114613((1E)-1-(3-bromophenyl)propan-1-one thiosemicarbazo...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50295129(5-(2-Amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597999(CHEMBL5198927)
Affinity DataIC50:  600nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50181473(4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)met...)
Affinity DataIC50:  880nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597993(ANETHOLTRITHION | Anethole Trithione | Anethole tr...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate in presence of NADH/alphaGDPH measure...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597988(CHEMBL5192352)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597987(CHEMBL5170853)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50332795(3-(4-methylphenyl)-5-oxo-4,5-dihydro-1,2,4-thiadia...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597990(CHEMBL3990589)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi TIM using glyceraldehyde 3-phosphate as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597994(CHEMBL5172018)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate in presence of NADH/alphaGDPH measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597991(CHEMBL5198783)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate preincubated for 2 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597998(CHEMBL5184910)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597992(CHEMBL5169735)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate preincubated for 2 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597989(CHEMBL1161789)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi TIM using glyceraldehyde 3-phosphate as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597997(CHEMBL5181562)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi Cruzaine using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured for 10 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597995(CHEMBL5189694)
Affinity DataKd:  24nMAssay Description:Displacement of [3H]-Eubricol from C-terminal His-tagged full-length Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli HMS174(DE3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597996(CHEMBL5196811)
Affinity DataKd:  160nMAssay Description:Inhibition of C-terminal His6-tagged Trypanosoma cruzi CYP51 expressed in Escherichia coli HMS174(DE3) assessed as dissociation constant by spectroph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed