Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50017452
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468103(US10800792, Example 768 | US10800792, Example 769 ...)
Affinity DataKi:  22nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468000(US10800792, Example 662 | (R)-N-(1-Acryloylpiperid...)
Affinity DataKi:  28nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataKi:  29nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467367(US10822348, Example 18 | (R)-N-(1-Acryloylpiperidi...)
Affinity DataKi:  32nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50601991(CHEMBL5206366)
Affinity DataKi:  49nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468010(US10800792, Example 672 | US10822348, Example 736 ...)
Affinity DataKi:  64nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467836(US10800792, Example 497 | (R)-N-(1-Acryloylpiperid...)
Affinity DataKi:  70nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468007(US10800792, Example 669 | US10822348, Example 722 ...)
Affinity DataKi:  145nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50601991(CHEMBL5206366)
Affinity DataIC50: 172nMAssay Description:Inhibition of recombinant human BMX by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468124(US10800792, Example 789 | US10822348, Example 804 ...)
Affinity DataKi:  208nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50601991(CHEMBL5206366)
Affinity DataIC50: 303nMAssay Description:Inhibition of recombinant human TEC by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467845(US10800792, Example 506 | (R)-N-(1-Acryloylpiperid...)
Affinity DataKi:  354nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467852(US10800792, Example 513 | (R)-N-(1-Acryloylpiperid...)
Affinity DataKi:  456nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50601991(CHEMBL5206366)
Affinity DataIC50: 558nMAssay Description:Inhibition of recombinant human BTK by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM468084(US10800792, Example 747 | US10822348, Example 756 ...)
Affinity DataKi:  2.55E+3nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50601991(CHEMBL5206366)
Affinity DataIC50: 3.13E+3nMAssay Description:Inhibition of recombinant human BLK by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50601990(CHEMBL5179679)
Affinity DataKi:  2.43E+5nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed